University of Rijeka

About: University of Rijeka is a education organization based out in Rijeka, Croatia. It is known for research contribution in the topics: Population & Tourism. The organization has 3471 authors who have published 7993 publications receiving 110386 citations. The organization is also known as: Rijeka University & Sveučilište u Rijeci.

Nonlinear IF Estimation Based on the Pseudo WVD Adapted Using the Improved Sliding Pairwise ICI Rule

Abstract: A method for the instantaneous frequency (IF) estimation of a monocomponent nonlinear frequency modulated (FM) signal based on the pseudo Wigner-Ville distribution (PWVD) with an adaptive window width is presented. In order to improve the IF estimation accuracy, the original sliding pair-wise intersection of confidence intervals (SPICI) rule has been modified. An additional criterion for a proper window width selection is introduced, which takes into account the amount of overlap between the current and the previous confidence interval relative to the current interval length. The presented results show that the proposed method outperforms the original SPICI-based method by up to 42% in terms of the mean absolute error and up to 73% in terms of the mean squared error. It is also less sensitive to the window widths set selection than the original method.

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents.

Abstract: Photodynamic therapy (PDT) combines a photosensitiser, light and molecular oxygen to induce oxidative stress that can be used to kill pathogens, cancer cells and other highly proliferative cells. There is a growing number of clinically approved photosensitisers and applications of PDT, whose main advantages include the possibility of selective targeting, localised action and stimulation of the immune responses. Further improvements and broader use of PDT could be accomplished by designing new photosensitisers with increased selectivity and bioavailability. Porphyrin-based photosensitisers with amphiphilic properties, bearing one or more positive charges, are an effective tool in PDT against cancers, microbial infections and, most recently, autoimmune skin disorders. The aim of the review is to present some of the recent examples of the applications and research that employ this specific group of photosensitisers. Furthermore, we will highlight the link between their structural characteristics and PDT efficiency, which will be helpful as guidelines for rational design and evaluation of new PSs.