Institution
University of Southern Denmark
Education•Odense, Syddanmark, Denmark•
About: University of Southern Denmark is a education organization based out in Odense, Syddanmark, Denmark. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 11928 authors who have published 37918 publications receiving 1258559 citations. The organization is also known as: SDU.
Papers published on a yearly basis
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TL;DR: Self‐reported chronic pain and other sequelae in a nationally representative sample of long‐term breast cancer survivors (BCS) are investigated.
224 citations
TL;DR: SART1 and heterogeneous nuclear RNP M were shown to be genuine SUMO targets, confirming the validity of the approach and eight novel potential SUMO-2 target proteins were identified by at least two peptides.
224 citations
University of Bergen1, University of Copenhagen2, National Institutes of Health3, National University of Ireland, Galway4, University of Turin5, Ghent University6, University of Siena7, Istanbul University8, University of Southern Denmark9, University of Hamburg10, University of Edinburgh11, Karolinska Institutet12, Paul Sabatier University13
TL;DR: Overweight prevalence in youth remained high across the countries examined and the primary factors linked to overweight were breakfast consumption and physical activity.
Abstract: Objectives:
To examine overweight prevalence and its association with demographic and lifestyle factors in 11–15 year olds in the HBSC 2005–2006 survey.
224 citations
TL;DR: In this article, the authors present data from all four sulfur isotopes that suggest that the internal fractionations associated with the sulfate reduction network are larger than previous estimates, and they construct a model of a traditional SRC network, as well as a more recent incarnation of the SRC with multiple sulfur intermediates.
224 citations
TL;DR: It is shown that protein-rich urine from nephrotic rats and from patients with nephRotic syndrome activate the epithelial sodium channel (ENaC) in cultured M-1 mouse collecting duct cells and in Xenopus laevis oocytes heterologously expressing ENaC.
Abstract: Proteinuria and increased renal reabsorption of NaCl characterize the nephrotic syndrome. Here, we show that protein-rich urine from nephrotic rats and from patients with nephrotic syndrome activate the epithelial sodium channel (ENaC) in cultured M-1 mouse collecting duct cells and in Xenopus laevis oocytes heterologously expressing ENaC. The activation depended on urinary serine protease activity. We identified plasmin as a urinary serine protease by matrix-assisted laser desorption/ionization time of-flight mass spectrometry. Purified plasmin activated ENaC currents, and inhibitors of plasmin abolished urinary protease activity and the ability to activate ENaC. In nephrotic syndrome, tubular urokinase-type plasminogen activator likely converts filtered plasminogen to plasmin. Consistent with this, the combined application of urokinase-type plasminogen activator and plasminogen stimulated amiloride-sensitive transepithelial sodium transport in M-1 cells and increased amiloride-sensitive whole-cell currents in Xenopus laevis oocytes heterologously expressing ENaC. Activation of ENaC by plasmin involved cleavage and release of an inhibitory peptide from the ENaC gamma subunit ectodomain. These data suggest that a defective glomerular filtration barrier allows passage of proteolytic enzymes that have the ability to activate ENaC.
223 citations
Authors
Showing all 12150 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Paul M. Ridker | 233 | 1242 | 245097 |
| George Davey Smith | 224 | 2540 | 248373 |
| Matthias Mann | 221 | 887 | 230213 |
| Eric Boerwinkle | 183 | 1321 | 170971 |
| Gang Chen | 167 | 3372 | 149819 |
| Jun Wang | 166 | 1093 | 141621 |
| Harvey F. Lodish | 165 | 782 | 101124 |
| Jens J. Holst | 160 | 1536 | 107858 |
| Rajesh Kumar | 149 | 4439 | 140830 |
| J. Fraser Stoddart | 147 | 1239 | 96083 |
| Debbie A Lawlor | 147 | 1114 | 101123 |
| Børge G. Nordestgaard | 147 | 1047 | 95530 |
| Oluf Pedersen | 135 | 939 | 106974 |
| Rasmus Nielsen | 135 | 556 | 84898 |
| Torben Jørgensen | 135 | 883 | 86822 |