Institution
University of Southern Denmark
Education•Odense, Syddanmark, Denmark•
About: University of Southern Denmark is a education organization based out in Odense, Syddanmark, Denmark. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 11928 authors who have published 37918 publications receiving 1258559 citations. The organization is also known as: SDU.
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TL;DR: This systematic review and meta-analysis showed that knee extensor muscle weakness was associated with an increased risk of developing knee osteoarthritis in both men and women.
322 citations
University of Manchester1, City University of New York2, Istanbul Technical University3, New York University4, Heidelberg University5, Niels Bohr Institute6, University of Edinburgh7, University of Bologna8, Academy of Athens9, Sapienza University of Rome10, University of Naples Federico II11, Stanford University12, Institut d'Astrophysique de Paris13, University of Portsmouth14, Cardiff University15, Universidade Federal do Espírito Santo16, University of Michigan17, Asia Pacific Center for Theoretical Physics18, University of New Mexico19, University of Barcelona20, University of St. Thomas (Minnesota)21, Princeton University22, National Autonomous University of Mexico23, California Institute of Technology24, INAF25, University of Chicago26, Michigan Technological University27, Lawrence Berkeley National Laboratory28, University of Cambridge29, Imperial College London30, Ruhr University Bochum31, University of Oxford32, University of Waterloo33, Johns Hopkins University34, University of Pennsylvania35, University of California, Davis36, Birla Institute of Technology and Science37, RWTH Aachen University38, Université libre de Bruxelles39, University of Padua40, Indian Institute of Technology Kharagpur41, Spanish National Research Council42, University of North Carolina at Chapel Hill43, University of Arizona44, University of Oslo45, Jamia Millia Islamia46, University of Southern Denmark47, National Institute for Space Research48, Fermilab49, Presidency University, Kolkata50, Université Paris-Saclay51, University of Montpellier52, University of Szczecin53, Korea Astronomy and Space Science Institute54, University of California, Los Angeles55, University of Paris56, Leiden University57, Swarthmore College58, University of Sheffield59, University of Amsterdam60, United College, Winnipeg61, Liaoning Normal University62
TL;DR: In this article, the authors focus on the 4.4σ tension between the Planck estimate of the Hubble constant H0 and the SH0ES collaboration measurements and discuss how the next decade's experiments will be crucial.
322 citations
TL;DR: In this paper, the authors suggest that political contestation is the primary mechanism driving policy responsiveness and that this, in turn, is mediated by political institutions and government popularity, and they analyze the responsiveness of executive policy promises (speeches) and policy actions (public expenditure) in Britain, Denmark, and the United States in the period from 1970 to 2005.
Abstract: Governments in democratic systems are expected to respond to the issue preferences of citizens. Yet we have a limited understanding of the factors that cause levels of responsiveness to vary across time and between countries. In this article, the authors suggest that political contestation is the primary mechanism driving policy responsiveness and that this, in turn, is mediated by political institutions and government popularity. To test this proposition, the authors analyze the responsiveness of executive policy promises (speeches) and policy actions (public expenditure) in Britain, Denmark, and the United States in the period from 1970 to 2005. These time-series analyses show that higher levels of political contestation are associated with more responsive executives.
322 citations
TL;DR: It is the time to begin the era of personalized prevention for knee OA, where prevention and early comprehensive-care models are the accepted norm, as is the case with other chronic diseases.
Abstract: Osteoarthritis (OA) has been thought of as a disease of cartilage that can be effectively treated surgically at severe stages with joint arthroplasty. Today, OA is considered a whole-organ disease that is amenable to prevention and treatment at early stages. OA develops slowly over 10-15 years, interfering with activities of daily living and the ability to work. Many patients tolerate pain, and many health-care providers accept pain and disability as inevitable corollaries of OA and ageing. Too often, health-care providers passively await final 'joint death', necessitating knee and hip replacements. Instead, OA should be viewed as a chronic condition, where prevention and early comprehensive-care models are the accepted norm, as is the case with other chronic diseases. Joint injury, obesity and impaired muscle function are modifiable risk factors amenable to primary and secondary prevention strategies. The strategies that are most appropriate for each patient should be identified, by selecting interventions to correct--or at least attenuate--OA risk factors. We must also choose the interventions that are most likely to be acceptable to patients, to maximize adherence to--and persistence with--the regimes. Now is the time to begin the era of personalized prevention for knee OA.
321 citations
TL;DR: Recombinant RGM at low nanomolar concentration induces collapse of temporal but not of nasal growth cones and guides temporal retinal axons in vitro, demonstrating its repulsive and axon-specific guiding activity.
Abstract: Axons rely on guidance cues to reach remote targets during nervous system development1. A well-studied model system for axon guidance is the retinotectal projection. The retina can be divided into halves; the nasal half, next to the nose, and the temporal half. A subset of retinal axons, those from the temporal half, is guided by repulsive cues expressed in a graded fashion in the optic tectum2,3, part of the midbrain. Here we report the cloning and functional characterization of a membrane-associated glycoprotein, which we call RGM (repulsive guidance molecule). This molecule shares no sequence homology with known guidance cues, and its messenger RNA is distributed in a gradient with increasing concentration from the anterior to posterior pole of the embryonic tectum. Recombinant RGM at low nanomolar concentration induces collapse of temporal but not of nasal growth cones and guides temporal retinal axons in vitro, demonstrating its repulsive and axon-specific guiding activity.
321 citations
Authors
Showing all 12150 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Paul M. Ridker | 233 | 1242 | 245097 |
| George Davey Smith | 224 | 2540 | 248373 |
| Matthias Mann | 221 | 887 | 230213 |
| Eric Boerwinkle | 183 | 1321 | 170971 |
| Gang Chen | 167 | 3372 | 149819 |
| Jun Wang | 166 | 1093 | 141621 |
| Harvey F. Lodish | 165 | 782 | 101124 |
| Jens J. Holst | 160 | 1536 | 107858 |
| Rajesh Kumar | 149 | 4439 | 140830 |
| J. Fraser Stoddart | 147 | 1239 | 96083 |
| Debbie A Lawlor | 147 | 1114 | 101123 |
| Børge G. Nordestgaard | 147 | 1047 | 95530 |
| Oluf Pedersen | 135 | 939 | 106974 |
| Rasmus Nielsen | 135 | 556 | 84898 |
| Torben Jørgensen | 135 | 883 | 86822 |