Institution
University of Southern Denmark
Education•Odense, Syddanmark, Denmark•
About: University of Southern Denmark is a education organization based out in Odense, Syddanmark, Denmark. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 11928 authors who have published 37918 publications receiving 1258559 citations. The organization is also known as: SDU.
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VU University Medical Center1, University of Crete2, North Shore-LIJ Health System3, Dresden University of Technology4, Karolinska Institutet5, New York University6, University of São Paulo7, University of Groningen8, National and Kapodistrian University of Athens9, University of Manchester10, University of Calgary11, Lupus Foundation of America12, University of Paris13, Semmelweis University14, University of Pécs15, Utrecht University16, University of Padua17, Charité18, University of Düsseldorf19, University of Birmingham20, Medical University of Graz21, Université catholique de Louvain22, University College London23, University of Cambridge24, University of Mainz25, Paris Descartes University26, Rio de Janeiro State University27, University of Paris-Sud28, Monash University29, University of Pisa30, Istanbul University31, University of Santo Tomas32, Johns Hopkins University33, Tel Aviv University34, Medical University of Vienna35, University of Brescia36, University of Toronto37, University of Porto38, University of Southern Denmark39, Veterans Health Administration40, Hairmyres Hospital41, National Institutes of Health42
TL;DR: An international task force of 60 specialists and patient representatives agreed on eight key statements regarding remission in SLE and three principles to guide the further development of remission definitions, which provides a framework for testing different definitions of remission against long-term outcomes.
Abstract: Objectives Treat-to-target recommendations have identified ‘remission’ as a target in systemic lupus erythematosus (SLE), but recognise that there is no universally accepted definition for this. Therefore, we initiated a process to achieve consensus on potential definitions for remission in SLE. Methods An international task force of 60 specialists and patient representatives participated in preparatory exercises, a face-to-face meeting and follow-up electronic voting. The level for agreement was set at 90%. Results The task force agreed on eight key statements regarding remission in SLE and three principles to guide the further development of remission definitions: 1. Definitions of remission will be worded as follows: remission in SLE is a durable state characterised by …………………. (reference to symptoms, signs, routine labs). 2. For defining remission, a validated index must be used, for example, clinical systemic lupus erythematosus disease activity index (SLEDAI)=0, British Isles lupus assessment group (BILAG) 2004 D/E only, clinical European consensus lupus outcome measure (ECLAM)=0; with routine laboratory assessments included, and supplemented with physician9s global assessment. 3. Distinction is made between remission off and on therapy: remission off therapy requires the patient to be on no other treatment for SLE than maintenance antimalarials; and remission on therapy allows patients to be on stable maintenance antimalarials, low-dose corticosteroids (prednisone ≤5 mg/day), maintenance immunosuppressives and/or maintenance biologics. The task force also agreed that the most appropriate outcomes (dependent variables) for testing the prognostic value (construct validity) of potential remission definitions are: death, damage, flares and measures of health-related quality of life. Conclusions The work of this international task force provides a framework for testing different definitions of remission against long-term outcomes.
243 citations
TL;DR: The data extend the number of known phosphorylation sites regulated by DNA damage, provides so far unprecedented temporal dissection of DNA damage-modifiedosphorylation events, and elucidate the cross-talk between different types of post-translational modifications in the dynamic regulation of a multifaceted DNA damage response.
243 citations
Monash University1, Laval University2, University of Warwick3, Griffith University4, University of Ottawa5, American Physical Therapy Association6, University of the West of England7, Radboud University Nijmegen8, University of British Columbia9, University of Sydney10, Okanagan College11, Bond University12, University of Otago13, University of South Australia14, La Trobe University15, University of Southern Denmark16, West Virginia University17, The George Institute for Global Health18, EHESP19, VU University Medical Center20, University of Edinburgh21, Utrecht University22, VU University Amsterdam23, University of Oxford24, King's College London25
TL;DR: The CERT, a 16-item checklist developed by an international panel of exercise experts, is designed to improve the reporting of exercise programs in all evaluative study designs and contains 7 categories: materials, provider, delivery, location, dosage, tailoring, and compliance.
Abstract: BACKGROUND: Exercise interventions are often incompletely described in reports of clinical trials, hampering evaluation of results and replication and implementation into practice. OBJECTIVE: The aim of this study was to develop a standardized method for reporting exercise programs in clinical trials: the Consensus on Exercise Reporting Template (CERT). DESIGN AND METHODS: Using the EQUATOR Network's methodological framework, 137 exercise experts were invited to participate in a Delphi consensus study. A list of 41 items was identified from a meta-epidemiologic study of 73 systematic reviews of exercise. For each item, participants indicated agreement on an 11-point rating scale. Consensus for item inclusion was defined a priori as greater than 70% agreement of respondents rating an item 7 or above. Three sequential rounds of anonymous online questionnaires and a Delphi workshop were used. RESULTS: There were 57 (response rate=42%), 54 (response rate=95%), and 49 (response rate=91%) respondents to rounds 1 through 3, respectively, from 11 countries and a range of disciplines. In round 1, 2 items were excluded; 24 items reached consensus for inclusion (8 items accepted in original format), and 16 items were revised in response to participant suggestions. Of 14 items in round 2, 3 were excluded, 11 reached consensus for inclusion (4 items accepted in original format), and 7 were reworded. Sixteen items were included in round 3, and all items reached greater than 70% consensus for inclusion. LIMITATIONS: The views of included Delphi panelists may differ from those of experts who declined participation and may not fully represent the views of all exercise experts. CONCLUSIONS: The CERT, a 16-item checklist developed by an international panel of exercise experts, is designed to improve the reporting of exercise programs in all evaluative study designs and contains 7 categories: materials, provider, delivery, location, dosage, tailoring, and compliance. The CERT will encourage transparency, improve trial interpretation and replication, and facilitate implementation of effective exercise interventions into practice.
243 citations
Max Planck Society1, Trinity College, Dublin2, University of Queensland3, University of Southern Denmark4, University of Amsterdam5, Woods Hole Oceanographic Institution6, University of Exeter7, University of Maryland, College Park8, University of Cape Town9, Hangzhou Normal University10, Radboud University Nijmegen11, Centre national de la recherche scientifique12, Princeton University13, University of California, Santa Cruz14, Hokkaido University15, National Autonomous University of Mexico16, Fisheries and Oceans Canada17, University of Sydney18, University of Plymouth19, Duke University20
TL;DR: The compadre Plant Matrix Database version 3.0 is introduced, an open‐source online repository containing 468 studies from 598 species world‐wide, with a total of 5621 matrices, a similarly data‐rich and ecologically relevant resource for plant demography.
Abstract: Summary 1 Schedules of survival, growth and reproduction are key life-history traits Data on how these traits vary among species and populations are fundamental to our understanding of the ecological conditions that have shaped plant evolution Because these demographic schedules determine population
243 citations
TL;DR: The mechanism behind the isomer-specific, CLA-mediated reduction in TG accumulation in differentiating human preadipocytes in vitro is investigated and both CLA isomers antagonized ligand-dependent activation of PPARgamma.
243 citations
Authors
Showing all 12150 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Paul M. Ridker | 233 | 1242 | 245097 |
| George Davey Smith | 224 | 2540 | 248373 |
| Matthias Mann | 221 | 887 | 230213 |
| Eric Boerwinkle | 183 | 1321 | 170971 |
| Gang Chen | 167 | 3372 | 149819 |
| Jun Wang | 166 | 1093 | 141621 |
| Harvey F. Lodish | 165 | 782 | 101124 |
| Jens J. Holst | 160 | 1536 | 107858 |
| Rajesh Kumar | 149 | 4439 | 140830 |
| J. Fraser Stoddart | 147 | 1239 | 96083 |
| Debbie A Lawlor | 147 | 1114 | 101123 |
| Børge G. Nordestgaard | 147 | 1047 | 95530 |
| Oluf Pedersen | 135 | 939 | 106974 |
| Rasmus Nielsen | 135 | 556 | 84898 |
| Torben Jørgensen | 135 | 883 | 86822 |