Institution
University of Southern Denmark
Education•Odense, Syddanmark, Denmark•
About: University of Southern Denmark is a education organization based out in Odense, Syddanmark, Denmark. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 11928 authors who have published 37918 publications receiving 1258559 citations. The organization is also known as: SDU.
Papers published on a yearly basis
Papers
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TL;DR: Exposure to endocrine-disrupting chemicals in the EU is likely to contribute substantially to disease and dysfunction across the life course with costs in the hundreds of billions of Euros per year.
Abstract: Context: Rapidly increasing evidence has documented that endocrine-disrupting chemicals (EDCs) contribute substantially to disease and disability. Objective: The objective was to quantify a range of health and economic costs that can be reasonably attributed to EDC exposures in the European Union (EU). Design: A Steering Committee of scientists adapted the Intergovernmental Panel on Climate Change weight-of-evidence characterization for probability of causation based upon levels of available epidemiological and toxicological evidence for one or more chemicals contributing to disease by an endocrine disruptor mechanism. To evaluate the epidemiological evidence, the Steering Committee adapted the World Health Organization Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group criteria, whereas the Steering Committee adapted definitions recently promulgated by the Danish Environmental Protection Agency for evaluating laboratory and animal evidence of endocrine disruption. Exp...
274 citations
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TL;DR: It is demonstrated that textured closed surfaces, i.e., particles made of perfect electric conductors (PECs), are able to support localized electromagnetic resonances with properties resembling those of localized surface plasmons (LSPs) in the optical regime and a metamaterial approach is presented that captures the basic ingredients of their electromagnetic response.
Abstract: We demonstrate that textured closed surfaces, i.e., particles made of perfect electric conductors (PECs), are able to support localized electromagnetic resonances with properties resembling those of localized surface plasmons (LSPs) in the optical regime. Because of their similar behavior, we name these types of resonances as spoof LSPs. As a way of example, we show the existence of spoof LSPs in periodically textured PEC cylinders and the almost perfect analogy to optical plasmonics. We also present a metamaterial approach that captures the basic ingredients of their electromagnetic response.
273 citations
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TL;DR: In this article, the authors proposed to increase the recycling rate and reduce landfill rate of C&D waste to improve the potential recycling economic values, but also dramatically reduce land use and potential environmental impacts.
273 citations
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TL;DR: It is concluded that some celiac disease patients have avenin-reactive mucosal T-cells that can cause mucosal inflammation and may be a reason for villous atrophy and inflammation in patients with Celiac disease who are eating oats but otherwise are adhering to a strict gluten-free diet.
Abstract: Background
Celiac disease is a small intestinal inflammatory disorder characterized by malabsorption, nutrient deficiency, and a range of clinical manifestations. It is caused by an inappropriate immune response to dietary gluten and is treated with a gluten-free diet. Recent feeding studies have indicated oats to be safe for celiac disease patients, and oats are now often included in the celiac disease diet. This study aimed to investigate whether oat intolerance exists in celiac disease and to characterize the cells and processes underlying this intolerance.
Methods and Findings
We selected for study nine adults with celiac disease who had a history of oats exposure. Four of the patients had clinical symptoms on an oats-containing diet, and three of these four patients had intestinal inflammation typical of celiac disease at the time of oats exposure. We established oats-avenin-specific and -reactive intestinal T-cell lines from these three patients, as well as from two other patients who appeared to tolerate oats. The avenin-reactive T-cell lines recognized avenin peptides in the context of HLA-DQ2. These peptides have sequences rich in proline and glutamine residues closely resembling wheat gluten epitopes. Deamidation (glutamine→glutamic acid conversion) by tissue transglutaminase was involved in the avenin epitope formation.
Conclusions
We conclude that some celiac disease patients have avenin-reactive mucosal T-cells that can cause mucosal inflammation. Oat intolerance may be a reason for villous atrophy and inflammation in patients with celiac disease who are eating oats but otherwise are adhering to a strict gluten-free diet. Clinical follow-up of celiac disease patients eating oats is advisable.
273 citations
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TL;DR: It is shown that the inclusion of various detergents can enhance the efficiency of this enrichment method, as phosphopeptides that otherwise adhere to plastic surfaces can be efficiently solubilized and subsequently purified.
Abstract: The complete characterization of phosphorylated proteins requires an efficient procedure for the enrichment of phosphopeptides from amongst a complicated peptide mixture. The sensitivity of the traditional immobilized metal affinity chromatography (IMAC) approach is severely affected by various buffers, detergents and other reagents normally utilized in biochemical and cell biological procedures, and thus pre-purification steps such as reversed-phase chromatography is required prior to phosphopeptide enrichment. Here we evaluate the use of different 'non-phosphopeptide-excluding compounds' in the loading buffer for titanium dioxide (TiO(2)) chromatography and show that TiO(2) is more robust and tolerant towards many reagents, including salts, detergents and other low molecular mass molecules, than conventional IMAC. In addition, we show that the inclusion of various detergents can enhance the efficiency of this enrichment method, as phosphopeptides that otherwise adhere to plastic surfaces can be efficiently solubilized and subsequently purified. The TiO(2) chromatography technique is also compared to zirconium dioxide chromatography for phosphopeptide enrichment.
273 citations
Authors
Showing all 12150 results
Name | H-index | Papers | Citations |
---|---|---|---|
Paul M. Ridker | 233 | 1242 | 245097 |
George Davey Smith | 224 | 2540 | 248373 |
Matthias Mann | 221 | 887 | 230213 |
Eric Boerwinkle | 183 | 1321 | 170971 |
Gang Chen | 167 | 3372 | 149819 |
Jun Wang | 166 | 1093 | 141621 |
Harvey F. Lodish | 165 | 782 | 101124 |
Jens J. Holst | 160 | 1536 | 107858 |
Rajesh Kumar | 149 | 4439 | 140830 |
J. Fraser Stoddart | 147 | 1239 | 96083 |
Debbie A Lawlor | 147 | 1114 | 101123 |
Børge G. Nordestgaard | 147 | 1047 | 95530 |
Oluf Pedersen | 135 | 939 | 106974 |
Rasmus Nielsen | 135 | 556 | 84898 |
Torben Jørgensen | 135 | 883 | 86822 |