Institution
University of Southern Denmark
Education•Odense, Syddanmark, Denmark•
About: University of Southern Denmark is a education organization based out in Odense, Syddanmark, Denmark. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 11928 authors who have published 37918 publications receiving 1258559 citations. The organization is also known as: SDU.
Papers published on a yearly basis
Papers
More filters
••
University of Vermont1, Babeș-Bolyai University2, University of Cologne3, Ankara University4, McGill University5, University of Coimbra6, Katholieke Universiteit Leuven7, Chuo University8, University of Missouri9, Norwegian University of Science and Technology10, The Chinese University of Hong Kong11, University of Pittsburgh12, Yonsei University13, University of Adelaide14, Harran University15, University of Zurich16, Medical University of Warsaw17, Chung Shan Medical University18, Mykolas Romeris University19, Erasmus University Rotterdam20, Bryn Mawr College21, University of Helsinki22, University of Southern Denmark23, Columbia University24, National Taiwan University25
TL;DR: Fit indices strongly supported the correlated 8-syndrome structure of the Child Behavior Checklist in each of 30 societies, which support use of the syndromes in diverse societies.
Abstract: There is a growing need for multicultural collaboration in child mental health services, training, and research. To facilitate such collaboration, this study tested the 8-syndrome structure of the Child Behavior Checklist (CBCL) in 30 societies. Parents' CBCL ratings of 58,051 6- to 18-year-olds were subjected to confirmatory factor analyses, which were conducted separately for each society. Societies represented Asia; Africa; Australia; the Caribbean; Eastern, Western, Southern, and Northern Europe; the Middle East; and North America. Fit indices strongly supported the correlated 8-syndrome structure in each of 30 societies. The results support use of the syndromes in diverse societies.
362 citations
••
TL;DR: A systematic evaluation of published evidence on neurotoxicity of pesticides in current use, with specific emphasis on risks during early development, concluded that the developing brain may be particularly vulnerable to adverse effects of neurotoxic pesticides.
Abstract: Pesticides used in agriculture are designed to protect crops against unwanted species, such as weeds, insects, and fungus. Many compounds target the nervous system of insect pests. Because of the similarity in brain biochemistry, such pesticides may also be neurotoxic to humans. Concerns have been raised that the developing brain may be particularly vulnerable to adverse effects of neurotoxic pesticides. Current requirements for safety testing do not include developmental neurotoxicity. We therefore undertook a systematic evaluation of published evidence on neurotoxicity of pesticides in current use, with specific emphasis on risks during early development. Epidemiologic studies show associations with neurodevelopmental deficits, but mainly deal with mixed exposures to pesticides. Laboratory experimental studies using model compounds suggest that many pesticides currently used in Europe – including organophosphates, carbamates, pyrethroids, ethylenebisdithiocarbamates, and chlorophenoxy herbicides – can cause neurodevelopmental toxicity. Adverse effects on brain development can be severe and irreversible. Prevention should therefore be a public health priority. The occurrence of residues in food and other types of human exposures should be prevented with regard to the pesticide groups that are known to be neurotoxic. For other substances, given their widespread use and the unique vulnerability of the developing brain, the general lack of data on developmental neurotoxicity calls for investment in targeted research. While awaiting more definite evidence, existing uncertainties should be considered in light of the need for precautionary action to protect brain development.
360 citations
••
TL;DR: Recent contributions to the field are described and factors that probably play a role in vivo are described, including Wnt, transforming growth factor beta, inflammatory cytokines and prostaglandin F(2alpha).
Abstract: The balance of contradictory signals experienced by preadipocytes influences whether these cells undergo adipogenesis. In addition to the endocrine system, these signals originate from the preadipocytes themselves or operate as part of a feedback loop involving mature adipocytes. The factors that regulate adipogenesis either promote or block the cascade of transcription factors that coordinate the differentiation process. Some of the positive factors reviewed include insulin-like growth factor I, macrophage colony-stimulating factor, fatty acids, prostaglandins and glucocorticoids, and negative factors reviewed include Wnt, transforming growth factor β, inflammatory cytokines and prostaglandin F 2α . Tipping the scales towards or away from adipogenesis has profound implications for human health. In this review, we describe recent contributions to the field and will focus on factors that probably play a role in vivo .
360 citations
••
TL;DR: The results suggest that human nuclear exosome degradation pathways comprise modules of spatially organized cofactors that diverge from the yeast model.
358 citations
••
TL;DR: The isotopic composition and concentration of molybdenum in sedimentary rocks are used to couple the redox history of the atmosphere and oceans to major events in animal evolution, suggesting two episodes of global ocean oxygenation and suggesting that early metazoans evolved in a relatively low oxygen environment.
Abstract: The evolution of Earth’s biota is intimately linked to the oxygenation of the oceans and atmosphere. We use the isotopic composition and concentration of molybdenum (Mo) in sedimentary rocks to explore this relationship. Our results indicate two episodes of global ocean oxygenation. The first coincides with the emergence of the Ediacaran fauna, including large, motile bilaterian animals, ca. 550–560 million year ago (Ma), reinforcing previous geochemical indications that Earth surface oxygenation facilitated this radiation. The second, perhaps larger, oxygenation took place around 400 Ma, well after the initial rise of animals and, therefore, suggesting that early metazoans evolved in a relatively low oxygen environment. This later oxygenation correlates with the diversification of vascular plants, which likely contributed to increased oxygenation through the enhanced burial of organic carbon in sediments. It also correlates with a pronounced radiation of large predatory fish, animals with high oxygen demand. We thereby couple the redox history of the atmosphere and oceans to major events in animal evolution.
358 citations
Authors
Showing all 12150 results
Name | H-index | Papers | Citations |
---|---|---|---|
Paul M. Ridker | 233 | 1242 | 245097 |
George Davey Smith | 224 | 2540 | 248373 |
Matthias Mann | 221 | 887 | 230213 |
Eric Boerwinkle | 183 | 1321 | 170971 |
Gang Chen | 167 | 3372 | 149819 |
Jun Wang | 166 | 1093 | 141621 |
Harvey F. Lodish | 165 | 782 | 101124 |
Jens J. Holst | 160 | 1536 | 107858 |
Rajesh Kumar | 149 | 4439 | 140830 |
J. Fraser Stoddart | 147 | 1239 | 96083 |
Debbie A Lawlor | 147 | 1114 | 101123 |
Børge G. Nordestgaard | 147 | 1047 | 95530 |
Oluf Pedersen | 135 | 939 | 106974 |
Rasmus Nielsen | 135 | 556 | 84898 |
Torben Jørgensen | 135 | 883 | 86822 |