University of Texas at Arlington

About: University of Texas at Arlington is a education organization based out in Arlington, Texas, United States. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 11758 authors who have published 28598 publications receiving 801626 citations. The organization is also known as: UT Arlington & University of Texas-Arlington.

Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases.

Abstract: 4-Hydroxy-trans-2-nonenal (HNE) was initially considered to be merely a toxic end product of lipid peroxidation that contributed to oxidative stress-related pathogenesis. However, in recent years its physiological role as an important "signaling molecule" has been established. HNE can modulate various signaling pathways in a concentration-dependent manner. Glutathione S-transferases (GSTs) are major determinants of the intracellular concentration of HNE, because these enzymes account for the metabolism of most cellular HNE through its conjugation to glutathione. Evidence is emerging that GSTs are involved in the regulation of the HNE-mediated signaling processes. Against the backdrop of our current understanding on the formation, metabolism, and role of HNE in signaling processes, the physiological role of GSTs in regulation of HNE-mediated signaling processes is critically evaluated in this chapter. Available evidence strongly suggests that besides their well-established pharmacological role of detoxifying xenobiotics, GSTs also play an important physiological role in the regulation of cellular signaling processes.

Part 8: Education, implementation, and teams. 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations

Abstract: Current evidence demonstrates considerable variability in cardiac arrest survival in and out of hospital and, therefore, substantial opportunity to save many more lives.1–3 The Formula for Survival4 postulates that optimal survival from cardiac arrest requires high-quality science, education of lay providers and healthcare professionals, and a well-functioning Chain of Survival5 (implementation). The Education, Implementation, and Teams (EIT) Task Force of the International Liaison Committee on Resuscitation (ILCOR) set out to define the key PICO (population, intervention, comparator, outcome) questions related to resuscitation education (including teamwork skills) and systems-level implementation that would be reviewed by 2015. The selection of questions was supported through the use of an online anonymous task force member–only voting process where the results were considered in the ultimate consensus decisions of the task force. Topics from the 2010 evidence review process were scrutinized for relevance, the potential to improve outcomes, and the likelihood of new evidence being published since 2010. Finally, PICO questions for which the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) process was not as well developed at the time of PICO selection were deferred until at least after the 2015 cycle. We planned to reduce the total number of PICO questions reviewed to provide more in-depth and evidence-based reviews of the included questions. New topics were determined on the basis of the evolving literature and changes in resuscitation practice. Input on the selection of PICO questions was sought from the general public through the ILCOR website and from ILCOR member resuscitation councils through their council chairs and individual task force members. The EIT Task Force performed detailed systematic reviews based on the recommendations of the Institute of Medicine of the National Academies6 and using the methodological approach proposed by the …

Interpersonal Conflict, Agreeableness, and Personality Development

Abstract: This multimethod research linked the Big-Five personality dimensions to interpersonal conflict in childhood. Agreeableness was the personality dimension of focus because this dimension has been associated with maintaining positive interpersonal relations in adolescents and adults. In two studies, elementary school children were assessed on the Big-Five domains of personality. Study 1 (n=276) showed that agreeableness was uniquely associated with endorsements of conflict resolution tactics in children as well as parent and teacher reports of coping and adjustment. Study 2 (n=234) revealed that children's perceptions of themselves and others during conflict was influenced by their agreeableness regardless of their partner's agreeableness. Observers also reported that pairs higher in agreeableness had more harmonious, constructive conflicts. Overall findings suggest that of the Big-Five dimensions, agreeableness is most closely associated with processes and outcomes related to interpersonal conflict and adjustment in children.

Combination of Tevatron searches for the standard model Higgs boson in the W+W- decay mode

Abstract: We combine searches by the CDF and D0 Collaborations for a Higgs boson decaying to W+W-. The data correspond to an integrated total luminosity of 4.8 (CDF) and 5.4 (D0) fb(-1) of p (p) over bar collisions at root s = 1.96 TeV at the Fermilab Tevatron collider. No excess is observed above background expectation, and resulting limits on Higgs boson production exclude a standard model Higgs boson in the mass range 162-166 GeV at the 95% C.L.