Institution
University of Westminster
Education•London, United Kingdom•
About: University of Westminster is a education organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 2944 authors who have published 8426 publications receiving 200236 citations. The organization is also known as: Westminster University & Royal Polytechnic Institution.
Topics: Population, Context (language use), Politics, Tourism, European union
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors explore the theoretical literature and review recent policy pronouncements relating to community involvement in England and discuss a recent case study of an Urban II project in London.
Abstract: Community involvement in the fields of town planning and urban regeneration includes a wide range of opportunities for residents and service users to engage with networks, partnerships and centres of power. Both the terminology and degree of the transfer of power to citizens varies in different policy areas and contexts but five core objectives can be identified. This article approaches the subject of community empowerment by exploring the theoretical literature; reviewing recent policy pronouncements relating to community involvement in England and by discussing a recent case study of an Urban II project in London. The conclusions suggest that community empowerment is always likely to be partial and contingent on local circumstances and the wider context.
67 citations
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01 Sep 2004TL;DR: An intelligent data-warehouse system consisting of an odour generation mechanism, rapid volatile delivery and recovery system, and a classifier system based on neural networks and genetic algorithms have been applied as part of a microbial analysis.
Abstract: There is increasing worldwide awareness that bionics and artificial intelligence will play an important role in microbial analysis. An intelligent data-warehouse system consisting of an odour generation mechanism, rapid volatile delivery and recovery system, and a classifier system based on neural networks and genetic algorithms have been applied as part of a microbial analysis. The microbiological warehouse environment has, also adopted the concept of fusion of multiple classifiers dedicated to specific feature parameters. The experimental results confirm the soundness of the presented methods.
67 citations
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03 Nov 1997TL;DR: This paper has created a tool for automatically binding existing native C libraries to Java, and has applied the Java-to-C Interface generating tool (JCI) to bind MPI to Java.
Abstract: In this paper we present a way of successfully tackling the difficulties of binding MPI to Java with a view to ensuring portability. We have created a tool for automatically binding existing native C libraries to Java, and have applied the Java-to-C Interface generating tool (JCI) to bind MPI to Java. The approach of automatic binding by JCI ensures both portability across different platforms and full compatibility with the MPI specification. To evaluate the resulting combination we have run a Java version of the NAS parallel IS benchmark on a distributed-memory IBM SP2 machine.
67 citations
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TL;DR: Two broadly neutralizing human monoclonal antibodies that represent a valid and affordable alternative to RIG in rabies PEP protected Syrian hamsters from a lethal RABV challenge and did not affect the endogenous hamster post‐vaccination antibody response.
Abstract: Currently available rabies post-exposure prophylaxis (PEP) for use in humans includes equine or human rabies immunoglobulins (RIG). The replacement of RIG with an equally or more potent and safer product is strongly encouraged due to the high costs and limited availability of existing RIG. In this study, we identified two broadly neutralizing human monoclonal antibodies that represent a valid and affordable alternative to RIG in rabies PEP. Memory B cells from four selected vaccinated donors were immortalized and monoclonal antibodies were tested for neutralizing activity and epitope specificity. Two antibodies, identified as RVC20 and RVC58 (binding to antigenic site I and III, respectively), were selected for their potency and broad-spectrum reactivity. In vitro, RVC20 and RVC58 were able to neutralize all 35 rabies virus (RABV) and 25 non-RABV lyssaviruses. They showed higher potency and breath compared to antibodies under clinical development (namely CR57, CR4098, and RAB1) and commercially available human RIG. In vivo, the RVC20-RVC58 cocktail protected Syrian hamsters from a lethal RABV challenge and did not affect the endogenous hamster post-vaccination antibody response.
67 citations
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TL;DR: The importance of N-linked glycosylation in modulating the response of cancer cells to chemotherapeutic and biological treatments is illustrated and the potential of glycosYLation inhibitors as future combination treatments for breast cancer is highlighted.
Abstract: Alterations in protein glycosylation are a key feature of oncogenesis and have been shown to affect cancer cell behaviour perturbing cell adhesion, favouring cell migration and metastasis. This study investigated the effect of N-linked glycosylation on the binding of Herceptin to HER2 protein in breast cancer and on the sensitivity of cancer cells to the chemotherapeutic agent doxorubicin (DXR) and growth factors (EGF and IGF-1). The interaction between Herceptin and recombinant HER2 protein and cancer cell surfaces (on-rate/off-rate) was assessed using a quartz crystal microbalance biosensor revealing an increase in the accessibility of HER2 to Herceptin following deglycosylation of cell membrane proteins (deglycosylated cells Bmax: 6.83 Hz; glycosylated cells Bmax: 7.35 Hz). The sensitivity of cells to DXR and to growth factors was evaluated using an MTT assay. Maintenance of SKBR-3 cells in tunicamycin (an inhibitor of N-linked glycosylation) resulted in an increase in sensitivity to DXR (0.1 μM DXR P < 0.001) and a decrease in sensitivity to IGF-1 alone and to IGF-1 supplemented with EGF (P < 0.001). This report illustrates the importance of N-linked glycosylation in modulating the response of cancer cells to chemotherapeutic and biological treatments and highlights the potential of glycosylation inhibitors as future combination treatments for breast cancer.
67 citations
Authors
Showing all 3028 results
Name | H-index | Papers | Citations |
---|---|---|---|
Barbara J. Sahakian | 145 | 612 | 69190 |
Peter B. Jones | 145 | 1857 | 94641 |
Andrew Steptoe | 137 | 1003 | 73431 |
Robert West | 112 | 1061 | 53904 |
Aldo R. Boccaccini | 103 | 1234 | 54155 |
Kevin Morgan | 95 | 655 | 49644 |
Shaogang Gong | 92 | 430 | 31444 |
Thomas A. Buchanan | 91 | 349 | 48865 |
Mauro Perretti | 90 | 497 | 28463 |
Jimmy D. Bell | 88 | 589 | 25983 |
Andrew D. McCulloch | 75 | 358 | 19319 |
Mark S. Goldberg | 73 | 235 | 18067 |
Dimitrios Buhalis | 72 | 316 | 23830 |
Ali Mobasheri | 69 | 370 | 14642 |
Michael E. Boulton | 69 | 331 | 23747 |