Utrecht University

About: Utrecht University is a education organization based out in Utrecht, Utrecht, Netherlands. It is known for research contribution in the topics: Population & Context (language use). The organization has 58176 authors who have published 139351 publications receiving 6214282 citations. The organization is also known as: UU & Universiteit Utrecht.

An Underground Revolution: Biodiversity and Soil Ecological Engineering for Agricultural Sustainability

Abstract: Soil organisms are an integral component of ecosystems, but their activities receive little recognition in agricultural management strategies. Here we synthesize the potential of soil organisms to enhance ecosystem service delivery and demonstrate that soil biodiversity promotes multiple ecosystem functions simultaneously (i.e., ecosystem multifunctionality). We apply the concept of ecological intensification to soils and we develop strategies for targeted exploitation of soil biological traits. We compile promising approaches to enhance agricultural sustainability through the promotion of soil biodiversity and targeted management of soil community composition. We present soil ecological engineering as a concept to generate human land-use systems, which can serve immediate human needs while minimizing environmental impacts.

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Abstract: Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obstacle by applying a centralized analysis pipeline to a SCZ cohort of 21,094 cases and 20,227 controls. A global enrichment of CNV burden was observed in cases (odds ratio (OR) = 1.11, P = 5.7 × 10-15), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 × 10-6). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 × 10-11) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 × 10-5). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.

Consistent increase in High Asia's runoff due to increasing glacier melt and precipitation

Abstract: Riv ers originating in the high mountains of Asia are among the most meltwater-dependent river systems on Earth, yet large human populations depend on their resources downstream 1 . Across High Asia’s river basins, there is large variation in the contribution of glacier and snow melt to total runo 2 , which is poorlyquantified.Thelackofunderstandingofthehydrological regimes of High Asia’s rivers is one of the main sources of uncertainty in assessing the regional hydrological impacts of climate change 3 . Here we use a large-scale, high-resolution cryospheric‐hydrological model to quantify the upstream hydrological regimes of the Indus, Ganges, Brahmaputra, Salween and Mekong rivers. Subsequently, we analyse the impacts of climate change on future water availability in these basins using the latest climate model ensemble. Despite large dierences in runo composition and regimes between basins and between tributaries within basins, we project an increase in runo at least until 2050 caused primarily by an increase in precipitation in the upper Ganges, Brahmaputra, Salween and Mekong basins and from accelerated melt in the upper Indus Basin. These findings have immediate consequences for climatechangepolicieswhereatransitiontowardscopingwith intra-annual shifts in water availability is desirable. In general, the climate in the eastern part of the Himalayas is characterized by the East-Asian and Indian monsoon systems, causing the bulk of precipitation to occur during JuneSeptember (Supplementary Fig. 4). The precipitation intensity shows a strong northsouth gradient caused by orographic eects 4 . Precipitation patterns in the Hindu Kush and Karakoram ranges in the west are characterized by westerly and southwesterly flows, causing the precipitation to fall more equally distributed over the year 5 (Supplementary Fig. 4). In the Karakoram, up to two-thirds of the annual high-altitude precipitation occurs during the winter months 6,7 . In addition, basin hypsometry determines the ratio of solid and liquid precipitation within a basin. Solid precipitation can be stored long-term as perennial snow, and ice or short-term as seasonal snow before turning into runo by melting, whereas liquid

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.

Abstract: LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. Here we find that the related RNF43 and ZNRF3 transmembrane E3 ubiquitin ligases are uniquely expressed in LGR5+ stem cells. Simultaneous deletion of the two genes encoding these proteins in the intestinal epithelium of mice induces rapidly growing adenomas containing high numbers of Paneth and LGR5+ stem cells. In vitro, growth of organoids derived from these adenomas is arrested when Wnt secretion is inhibited, indicating a dependence of the adenoma stem cells on Wnt produced by adenoma Paneth cells. In the HEK293T human cancer cell line, expression of RNF43 blocks Wnt responses and targets surface-expressed frizzled receptors to lysosomes. In the RNF43-mutant colorectal cancer cell line HCT116, reconstitution of RNF43 expression removes its response to exogenous Wnt. We conclude that RNF43 and ZNRF3 reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation.