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Institution

Utrecht University

EducationUtrecht, Utrecht, Netherlands
About: Utrecht University is a education organization based out in Utrecht, Utrecht, Netherlands. It is known for research contribution in the topics: Population & Context (language use). The organization has 58176 authors who have published 139351 publications receiving 6214282 citations. The organization is also known as: UU & Universiteit Utrecht.


Papers
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Journal ArticleDOI
14 Jan 2000-Science
TL;DR: The real-space dynamics in a model system of colloidal hard spheres was studied by means of time-resolved fluorescence confocal scanning microscopy for direct experimental evidence for the presence of dynamical heterogeneities in a dense liquid.
Abstract: The real-space dynamics in a model system of colloidal hard spheres was studied by means of time-resolved fluorescence confocal scanning microscopy. Direct experimental evidence for the presence of dynamical heterogeneities in a dense liquid was obtained from an analysis of particle trajectories in two-dimensional slices of the bulk sample. These heterogeneities manifest themselves as a non-Gaussian probability distribution of particle displacements and also affect the onset of long-time diffusive behavior.

715 citations

Journal ArticleDOI
TL;DR: In this paper, the factorial validity of the Maslach Burnout Inventory-General Survey (MBI-GS) was investigated among employees of a multinational company in the forest industry.
Abstract: The factorial validity of the Maslach Burnout Inventory-General Survey (MBI-GS) was investigated among employees of a multinational company in the forest industry. The present study includes data from Finnish, Swedish and Dutch employees (total N = 9055). The hypothesized three-factor model of the MBI-GS (Exhaustion, Cynicism, Professional Efficacy) was replicated across occupational groups (i.e. managers, clerks, foremen technicians, blue-collar workers) and nations. The fit of this model to the data was superior to alternative one- and two-factor models in all samples under investigation. In addition, the three-factor structure of the MBI-GS proved invariant across all occupational groups. The internal consistencies of the three subscales are satisfactory, except for the cynicism scale in some subsamples. Therefore, it is suggested to exclude one—ambiguous—cynicism item. Finally, some differences in levels of burnout are found between nations and occupational groups that are consistent with earlier findings.

715 citations

Journal ArticleDOI
TL;DR: In this paper, an overview is presented of the different approaches to generate and characterize mesopores in zeolite crystals and establish their impact on the catalytic action, and it is shown that electron tomography, a form of threedimensional transmission electron microscopy, is able to reveal the three-dimensional shape, size, and connectivity of the mesopore.
Abstract: Amongst the current developments in the field of hierarchical pore structures, the creation of mesopores in zeolite crystals is the most frequently employed way to combine micropores with mesopores in one material. In this review an overview is presented of the different approaches to generate and characterize mesopores in zeolite crystals and establish their impact on the catalytic action. Mesopores can be created via several routes from which steaming and acid leaching are the most frequently applied. Novel approaches using secondary carbon templates that are removed after synthesis have recently been launched. For the characterization of mesopores, nitrogen physisorption and electron microscopy are commonly used. More recently, it was shown that electron tomography, a form of three-dimensional transmission electron microscopy, is able to reveal the three-dimensional shape, size, and connectivity of the mesopores. The effect of the presence of mesopores for catalysis is demonstrated for several industri...

714 citations

Journal ArticleDOI
TL;DR: The current 3C-based methods are evaluated and compared, their contribution to the current understanding of genome structure is summarized, and how shape influences genome function is discussed.
Abstract: Over the past 10 years, the development of chromosome conformation capture (3C) technology and the subsequent genomic variants thereof have enabled the analysis of nuclear organization at an unprecedented resolution and throughput. The technology relies on the original and, in hindsight, remarkably simple idea that digestion and religation of fixed chromatin in cells, followed by the quantification of ligation junctions, allows for the determination of DNA contact frequencies and insight into chromosome topology. Here we evaluate and compare the current 3C-based methods (including 4C [chromosome conformation capture-on-chip], 5C [chromosome conformation capture carbon copy], HiC, and ChIA-PET), summarize their contribution to our current understanding of genome structure, and discuss how shape influences genome function.

714 citations


Authors

Showing all 58756 results

NameH-indexPapersCitations
Ronald C. Kessler2741332328983
Albert Hofman2672530321405
Douglas G. Altman2531001680344
Hans Clevers199793169673
Craig B. Thompson195557173172
Patrick W. Serruys1862427173210
Ruedi Aebersold182879141881
Dennis S. Charney179802122408
Kenneth S. Kendler1771327142251
Jean Louis Vincent1611667163721
Vilmundur Gudnason159837123802
Monique M.B. Breteler15954693762
Lex M. Bouter158767103034
Elio Riboli1581136110499
Roy F. Baumeister157650132987
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023429
20221,014
20218,993
20208,578
20197,862
20187,020