Journal ArticleDOI
A CMOS Cantilever-Based Label-Free DNA SoC With Improved Sensitivity for Hepatitis B Virus Detection
Yu-Jie Huang,Che-Wei Huang,Tsung-Hsien Lin,Chih-Ting Lin,Li-Guang Chen,Po-Yun Hsiao,Bi-Ru Wu,Hsiao-Ting Hsueh,Bing-Jye Kuo,Hann-Huei Tsai,Hsin-Hao Liao,Ying-Zong Juang,Chorng-Kuang Wang,Shey-Shi Lu +13 more
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TLDR
This paper presents a highly-integrated DNA detection SoC, where several kinds of cantilever DNA sensors, a readout circuit, an MCU, voltage regulators, and a wireless transceiver are integrated monolithically in a 0.35 μm CMOS Bio-MEMS process.Abstract:
This paper presents a highly-integrated DNA detection SoC, where several kinds of cantilever DNA sensors, a readout circuit, an MCU, voltage regulators, and a wireless transceiver, are integrated monolithically in a 0.35 μm CMOS Bio-MEMS process. The cantilever-based biosensors with embedded piezoresistors aim to transduce DNA hybridization into resistance variation without cumbersome labeling process. To improve detection sensitivity for low DNA concentration use, an oscillator-based self-calibrated readout circuit with high precision is proposed to convert small resistance variation ( of original resistance) of the sensor into adequate frequency variation and further into digital data. Moreover, its wireless capacity enables isolation of the sample solution from electrical wire lines and facilitates data transmission. To demonstrate the effectiveness of full system, it is applied to detect hepatitis B virus (HBV) DNA. The experimental results show that it has the capability to distinguish between one base-pair (1-bp) mismatch DNAs and match DNAs and achieves a limit of detection (LOD) of less than 1 pM.read more
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Journal ArticleDOI
A Self-Powered CMOS Reconfigurable Multi-Sensor SoC for Biomedical Applications
Yu-Jie Huang,Te-Hsuen Tzeng,Tzu-Wei Lin,Che-Wei Huang,Pei-Wen Yen,Po-Hung Kuo,Chih-Ting Lin,Shey-Shi Lu +7 more
TL;DR: A highly adaptive multi-sensor SoC comprising four on-chip sensors and a smart wireless acquisition system is first realized in standard CMOS process and Experimental results show that four physiological parameters can be simultaneously monitored using this chip.
Microcantilever based Biosensor for Disease Detection Applications
TL;DR: In this article, the authors review the principle of microcantilever, biosensing mechanism and applications of micro cantilevers for bio detection for early detection of diseases accurately, the main advantages of MEMS based sensors are specificity, portability, simplicity, high sensitivity, potential ability for real-time and onsite analysis coupled with the high speed and low cost.
Journal ArticleDOI
CMOS biosensors for in vitro diagnosis – transducing mechanisms and applications
TL;DR: The recent advances in CMOS biosensors are detailed, centering on their key principles, requisites, and applications, which may contribute to the advancement of the healthcare system, which should be decentralized by broadly utilizing point-of-care diagnostic tools.
Journal ArticleDOI
A $\mu $ NMR CMOS Transceiver Using a Butterfly-Coil Input for Integration With a Digital Microfluidic Device Inside a Portable Magnet
TL;DR: A 20 MHz micro-nuclear magnetic resonance (μNMR) transceiver featuring a butterfly-coil input for chemical/biological assays enables integration with a 2D multi-electrode digital microfluidic device inside a space-limited portable magnet, making multi-sample management compatible with μNMR measurements, and supporting electronic automation.
Journal ArticleDOI
A tunable ferroelectric based unreleased RF resonator.
TL;DR: In this paper, a tunable ferroelectric capacitor (FeCAP)-based unreleased RF MEMS resonator, integrated seamlessly in Texas Instruments’ 130 nm Ferroelectric RAM (FeRAM) technology, is presented.
References
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