A new flavanone and other flavonoids from green perilla leaf extract inhibit nitric oxide production in interleukin 1β-treated hepatocytes
Ayaka Nakajima,Yuka Yamamoto,Nao Yoshinaka,Mayuri Namba,Hirotaka Matsuo,Tetsuya Okuyama,Emi Yoshigai,Tadayoshi Okumura,Mikio Nishizawa,Yukinobu Ikeya +9 more
Reads0
Chats0
TLDR
The present findings suggest that these constituents, including shisoflavanone A, may be involved in the anti-inflammatory effects of green perilla leaves.Abstract:
A new flavanone, shisoflavanone A (1), and several flavonoids were purified from the ethyl acetate-soluble fraction of green perilla leaves (Perilla frutescens Britton var. crispa form viridis), and their structures were identified. Shisoflavanone A was elucidated as 8-hydroxy-6,7-dimethoxyflavanone based on its spectral data. Other constituents of the ethyl acetate-soluble fraction, i.e. 5,8-dihydroxy-7-methoxyflavanone (2), negletein (5,6-dihydroxy-7-methoxyflavone) (3), luteolin (4), apigenin (5), esculetin (6), and protocatechuic acid (7), were identified. This is the first time that constituents 2, 3, and 6 have been found in green perilla. Shisoflavanone A and the other constituents (except 7) significantly inhibited nitric oxide production in interleukin 1β-stimulated rat hepatocytes, which have been used to monitor the anti-inflammatory effects of herbal constituents. The present findings suggest that these constituents, including shisoflavanone A, may be involved in the anti-inflammatory effects of green perilla leaves.read more
Citations
More filters
Journal ArticleDOI
Exploring the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Glycyrrhizic and Glycyrrhetinic Acids.
TL;DR: The anti-inflammatory mechanism of glycyrrhizic (GL) and glycyrrhetinic acid (GA) is realized via cytokines like interferon-γ, tumor necrotizing factor-α, interleukin- (IL-) 1β, IL-4, IL 5, IL 6, IL 7, IL 8, IL 9, IL 10, IL 11, IL 12, IL 14, IL 15, IL 16, and IL 17 as mentioned in this paper.
Journal ArticleDOI
The constituents of licorice (Glycyrrhiza uralensis) differentially suppress nitric oxide production in interleukin-1β-treated hepatocytes.
Ryunosuke Tanemoto,Tetsuya Okuyama,Hirotaka Matsuo,Tadayoshi Okumura,Yukinobu Ikeya,Mikio Nishizawa +5 more
TL;DR: Both glycyrrhizin and the minor constituents may be responsible for the anti-inflammatory effects of G. uralensis, and it is implied that these constituents may have a therapeutic potential for inflammatory hepatic disorders.
Journal ArticleDOI
Preparation and evaluation of a novel N-benzyl-phenethylamino-β-cyclodextrin-bonded chiral stationary phase for HPLC
TL;DR: A novel N-benzyl-phenethylamino-β-cyclodextrin-bonded ordered mesoporous SBA-15 chiral stationary phase (BZCDP) for high-performance liquid chromatography (HPLC) was prepared as discussed by the authors.
Journal ArticleDOI
Perilla frutescens leaves extract ameliorates ultraviolet radiation-induced extracellular matrix damage in human dermal fibroblasts and hairless mice skin.
Jung Soo Bae,Mira Han,Hee Soon Shin,Min Kyoung Kim,Chang Yup Shin,Dong Hun Lee,Dong Hun Lee,Dong Hun Lee,Jin Ho Chung +8 more
TL;DR: It is suggested that Perilla frutescens leaves extract can be a potential agent for prevention of skin aging because of its protective effect against UV-induced dermal matrix damage.
Journal ArticleDOI
Comparative analysis of the constituents in Saposhnikoviae Radix and Glehniae Radix cum Rhizoma by monitoring inhibitory activity of nitric oxide production.
TL;DR: Monitoring levels of the inflammatory mediator nitric oxide produced in rat hepatocytes suggested that linear dihydropyranochromones and coumarins are responsible for the anti-inflammatory effects of Bofu and Hamabofu.
References
More filters
Journal ArticleDOI
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Laura C. Green,David A. Wagner,Joseph A. Glogowski,Paul L. Skipper,John S. Wishnok,Steven R. Tannenbaum +5 more
TL;DR: A new automated system for the analysis of nitrate via reduction with a high-pressure cadmium column that automatically eliminates interference from other compounds normally present in urine and other biological fluids is described.
Journal ArticleDOI
International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors
Françoise Bachelerie,Adit Ben-Baruch,Amanda M. Burkhardt,Christophe Combadière,Joshua M. Farber,Gerard J. Graham,Richard Horuk,Alexander Hovard Sparre-Ulrich,Massimo Locati,Andrew D. Luster,Alberto Mantovani,Kouji Matsushima,Philip M. Murphy,Robert J. B. Nibbs,Hisayuki Nomiyama,Christine Power,Amanda E. I. Proudfoot,Mette M. Rosenkilde,Antal Rot,Silvano Sozzani,Marcus Thelen,Osamu Yoshie,Albert Zlotnik +22 more
TL;DR: This work reviews this extended family of chemokine receptors and Chemokine-binding proteins at the basic, translational, and clinical levels, including an update on drug development and introduces a new nomenclature for atypical chemokin receptors with the stem ACKR (atypicalChemokine receptor).
Journal ArticleDOI
The dual personality of NO.
Marco Colasanti,Hisanori Suzuki +1 more
TL;DR: Recent evidence is highlighted that supports the complexity of the regulatory mechanisms that lead to sophisticated endogenous NO production.
Journal ArticleDOI
Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens.
TL;DR: Results suggest that luteolin is a genuinely active constituent which is accountable for the oral effects of perilla, and the inhibitory activity of TNF-alpha production in vitro is used as the index for isolation.
Journal ArticleDOI
Triterpene Acids from the Leaves of Perilla frutescens and Their Anti-inflammatory and Antitumor-promoting Effects
Norihiro Banno,Toshihiro Akihisa,Harukuni Tokuda,Ken Yasukawa,Hiroshi Higashihara,Motohiko Ukiya,Kenji Watanabe,Yumiko Kimura,Jun-ichi Hasegawa,Hoyoku Nishino +9 more
TL;DR: Eight triterpene acids isolated from ethanol extracts of the leaves of red and green perilla exhibited strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter.