A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Diego Ghezzi,Maria Rosa Antognazza,Rita Maccarone,Sebastiano Bellani,Sebastiano Bellani,Erica Lanzarini,Nicola Martino,Nicola Martino,Maurizio Mete,Grazia Pertile,Silvia Bisti,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati +13 more
Reads0
Chats0
TLDR
It is demonstrated that this bio-organic interface restored light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration, suggesting that all-organic devices may play an important future role in sub-retinal prosthetic implants.Abstract:
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with lightinduced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants.read more
Citations
More filters
Journal ArticleDOI
The rise of plastic bioelectronics
TL;DR: Plastic bioelectronics is a research field that takes advantage of the inherent properties of polymers and soft organic electronics for applications at the interface of biology and electronics, which are soft, stretchable and mechanically conformable.
Journal ArticleDOI
Electronic Skin: Recent Progress and Future Prospects for Skin‐Attachable Devices for Health Monitoring, Robotics, and Prosthetics
TL;DR: Recent progress in electronic skin or e‐skin research is broadly reviewed, focusing on technologies needed in three main applications: skin‐attachable electronics, robotics, and prosthetics.
Journal ArticleDOI
Organic Photodiodes: The Future of Full Color Detection and Image Sensing
TL;DR: Organic photodiodes (OPDs) are beginning to rival their inorganic counterparts in a number of performance criteria including the linear dynamic range, detectivity, and color selectivity.
Journal ArticleDOI
Organic Bioelectronics: Bridging the Signaling Gap between Biology and Technology.
TL;DR: The field of organic bioelectronics is introduced, from its early breakthroughs to its current results and future challenges, and is maturing toward applications ranging from life sciences to the clinic.
Journal ArticleDOI
Next-generation probes, particles, and proteins for neural interfacing
Jonathan Rivnay,Jonathan Rivnay,Huiliang Wang,Lief E. Fenno,Karl Deisseroth,George G. Malliaras +5 more
TL;DR: This Review describes how the understanding of neural signaling and material-tissue interactions has fueled the expansion of the available tool set and will support new neurotherapies and prostheses and provide neuroscientists and neurologists with unprecedented access to the brain.
References
More filters
Related Papers (5)
A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness
José Fernando Maya-Vetencourt,Diego Ghezzi,Diego Ghezzi,Maria Rosa Antognazza,Elisabetta Colombo,Maurizio Mete,Paul Feyen,Andrea Desii,Ambra Buschiazzo,Mattia Di Paolo,Stefano Di Marco,Flavia Ticconi,Laura Emionite,Dmytro Shmal,Cecilia Marini,Ilaria Donelli,Giuliano Freddi,Rita Maccarone,Silvia Bisti,Gianmario Sambuceti,Grazia Pertile,Guglielmo Lanzani,Fabio Benfenati,Fabio Benfenati +23 more