A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Diego Ghezzi,Maria Rosa Antognazza,Rita Maccarone,Sebastiano Bellani,Sebastiano Bellani,Erica Lanzarini,Nicola Martino,Nicola Martino,Maurizio Mete,Grazia Pertile,Silvia Bisti,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati +13 more
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TLDR
It is demonstrated that this bio-organic interface restored light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration, suggesting that all-organic devices may play an important future role in sub-retinal prosthetic implants.Abstract:
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with lightinduced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants.read more
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Semiconducting electrodes for neural interfacing: a review.
TL;DR: Semiconducting electrodes have advanced electrically based neural interfacing technologies owing to their unique electrochemical and photo-electrochemical attributes as mentioned in this paper , which can facilitate electrical, optical, and chemical sensing and modulation with high spatial and temporal precision.
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Visual Prostheses: Neuroengineering Handbook
TL;DR: Visual prostheses are devices that aim to provide artificial vision to those with vision loss by stimulating surviving functional neurons in the visual pathway as mentioned in this paper , which can work by stimulating the retina, optic tract, and visual cortex.
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Photoelectrochemical Modelling of Semiconducting Electrodes for Neural Interfacing
TL;DR: In this article , an equivalent circuit model that simultaneously describes the results from cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and photocurrent (PC) transient measurements is presented.
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Design Optimization and Characterization with Fabrication of Nanomaterials-Based Photo Diode Cell for Subretinal Implant Application
TL;DR: In this article , an ultrathin nano photodiode array fabricated in a flexible substrate can be an ideal therapeutic replacement for degenerated photoreceptor cells damaged by Age-related Macula Degeneration (AMD) and Retinitis Pigmentosa (RP), such as retinal infections.
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Retinal Repair by Transplantation of Photoreceptor Precursors
Robert E MacLaren,Rachael A. Pearson,A MacNeil,Ronald H. Douglas,Thomas E. Salt,Masayuki Akimoto,Anand Swaroop,Jane C. Sowden,Robin R. Ali +8 more
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Subretinal electronic chips allow blind patients to read letters and combine them to words
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