A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Diego Ghezzi,Maria Rosa Antognazza,Rita Maccarone,Sebastiano Bellani,Sebastiano Bellani,Erica Lanzarini,Nicola Martino,Nicola Martino,Maurizio Mete,Grazia Pertile,Silvia Bisti,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati +13 more
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TLDR
It is demonstrated that this bio-organic interface restored light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration, suggesting that all-organic devices may play an important future role in sub-retinal prosthetic implants.Abstract:
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with lightinduced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants.read more
Citations
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Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis
Laura Ferlauto,Marta Jole Ildelfonsa Airaghi Leccardi,Naïg Aurelia Ludmilla Chenais,Samuel Charles Antoine Gilliéron,Paola Vagni,Michele Bevilacqua,Thomas J. Wolfensberger,Kevin Sivula,Diego Ghezzi +8 more
TL;DR: A foldable and wide-field epiretinal prosthesis that can meet the performance and safety requirements and show a long lifetime of 2 years, designed by Ferlauto et al.
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Nanotechnology-based biomaterials for orthopaedic applications: Recent advances and future prospects.
TL;DR: The present review lays the foundation for nanotechnology-driven biomaterials through revelation of fundamental design considerations to determine the performance of an orthopaedic implant in terms of success or failure, their antimicrobial/antibacterial activities, and response to cell adhesion, proliferation, and differentiation.
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Nanotransducers for Near-Infrared Photoregulation in Biomedicine.
TL;DR: The emerging applications, including photoregulation of neural activity, gene expression, and visual systems, as well as photochemical tissue bonding, are highlighted, along with the design principles of nanotransducers.
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Direct Electrical Neurostimulation with Organic Pigment Photocapacitors
David M. Rand,Marie Jakešová,Gur Lubin,Ieva Vėbraitė,Moshe David-Pur,Vedran Đerek,Tobias Cramer,Niyazi Serdar Sariciftci,Yael Hanein,Eric Daniel Głowacki +9 more
TL;DR: The results substantiate the conclusion that these devices are the first non-Si optoelectronic platform capable of sufficiently large photovoltages and displacement currents to enable true capacitive stimulation of excitable cells.
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A polymer optoelectronic interface provides visual cues to a blind retina.
TL;DR: The polymer interface can be used as an optoelectronic epiretinal interface for retinal prosthesis with no requirement for external power sources or connection cables.
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