A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Diego Ghezzi,Maria Rosa Antognazza,Rita Maccarone,Sebastiano Bellani,Sebastiano Bellani,Erica Lanzarini,Nicola Martino,Nicola Martino,Maurizio Mete,Grazia Pertile,Silvia Bisti,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati +13 more
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TLDR
It is demonstrated that this bio-organic interface restored light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration, suggesting that all-organic devices may play an important future role in sub-retinal prosthetic implants.Abstract:
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with lightinduced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants.read more
Citations
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Journal ArticleDOI
Retinal Prosthetic Approaches to Enhance Visual Perception for Blind Patients.
TL;DR: A comprehensive and up-to-date overview of retinal prosthetic strategies is provided, with a specific focus on a quantitative assessment of visual acuity results from various retinal stimulation technologies.
Journal ArticleDOI
The study of polythiophene/water interfaces by sum-frequency generation spectroscopy and molecular dynamics simulations.
Sebastiano Bellani,Sebastiano Bellani,Matteo Porro,Matteo Porro,Claudia Caddeo,Maria Ilenia Saba,Paulo B. Miranda,Alessandro Mattoni,Guglielmo Lanzani,Guglielmo Lanzani,Maria Rosa Antognazza +10 more
TL;DR: Sum-frequency generation vibrational spectroscopy is employed, a surface-specific technique compatible with electrochemical/biological conditions, to demonstrate that the surface of thin films of regio-regular poly-3-hexylthiophene (rr-P3HT) undergoes a molecular reorientation when exposed to aqueous electrolytes, with respect to their surface structure in air.
Journal ArticleDOI
Biological Considerations of Optical Interfaces for Neuromodulation
William L. Hart,Tatiana Kameneva,Tatiana Kameneva,Andrew K. Wise,Andrew K. Wise,Paul R. Stoddart +5 more
TL;DR: This review presents the status of optical interface technologies with a focus on biological considerations, such as biocompatibility, thermal loading, and tissue response, and issues around reliability and manufacturing that need to be considered for successful translation.
Journal ArticleDOI
Plasmon-Coupled Photocapacitor Neuromodulators.
Rustamzhon Melikov,Shashi Bhushan Srivastava,Onuralp Karatum,Itir Bakis Dogru,Houman Bahmani Jalali,Sadra Sadeghi,Ugur Meric Dikbas,Burak Ulgut,Ibrahim Halil Kavakli,Arif E. Cetin,Sedat Nizamoglu +10 more
TL;DR: This study demonstrates that plasmonic coupling to photocapacitor biointerfaces improves safe and efficacious neuromodulating displacement charges for an average of 185% in the entire visible spectrum while maintaining the faradic currents below 1%.
Journal ArticleDOI
A lysinated thiophene-based semiconductor as a multifunctional neural bioorganic interface.
Simone Bonetti,Assunta Pistone,Marco Brucale,Saskia Karges,Laura Favaretto,Massimo Zambianchi,Tamara Posati,Anna Sagnella,Marco Caprini,Stefano Toffanin,Roberto Zamboni,Nadia Camaioni,Michele Muccini,Manuela Melucci,Valentina Benfenati +14 more
TL;DR: An innovative concept for organic material neural interface that combines optical and iono‐electronic functionalities with improved biocompatibility and neuron affinity promoted by Lys linkage and the softness of organic semiconductors is introduced.
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