A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Diego Ghezzi,Maria Rosa Antognazza,Rita Maccarone,Sebastiano Bellani,Sebastiano Bellani,Erica Lanzarini,Nicola Martino,Nicola Martino,Maurizio Mete,Grazia Pertile,Silvia Bisti,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati +13 more
Reads0
Chats0
TLDR
It is demonstrated that this bio-organic interface restored light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration, suggesting that all-organic devices may play an important future role in sub-retinal prosthetic implants.Abstract:
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with lightinduced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants.read more
Citations
More filters
Journal ArticleDOI
From cage-jump motion to macroscopic diffusion in supercooled liquids
TL;DR: In this paper, the authors present a detailed characterization of the statistical features of the single-particle intermittent motion of structural glasses, and show that single particle jumps are the irreversible events leading to the relaxation of the system.
Journal ArticleDOI
Colloidal self-assembly of soft neural interfaces from injectable photovoltaic microdevices
TL;DR: In this article , a minimally invasive strategy based on in situ self-assembly of photovoltaic microdevices (PVMs) is presented, where photoelectricity transduced by PVMs upon visible light illumination reaches the intensity levels that could effectively activate the retinal ganglion cell layers.
Journal ArticleDOI
In Vitro Cytotoxicity of D18 and Y6 as Potential Organic Photovoltaic Materials for Retinal Prostheses
Ana Cetkovic,Alessandro Bellapianta,Mihai Irimia-Vladu,Jakob Hofinger,Cigdem Yumusak,Andrea Corna,Markus C. Scharber,Günther Zeck,Niyazi Serdar Sariciftci,Matthias Bolz,Ahmad Salti +10 more
TL;DR: It is concluded that D18/Y6 is safe to be subsequently investigated as a retinal prosthesis and all in vitro experiments show no cytotoxicity of D18 and Y6 alone or as a D18-Y6 mixture.
Journal ArticleDOI
Flexible Optoelectronic Sensors: Status and Prospect
Zhuoran Wang,Guozhen Shen +1 more
TL;DR: Different from conventional circuits made of bulky semiconductors, flexible electronics bring mechanical flexibility and remove form factor constrains in highly functional systems, which stimulate innovative applications as mentioned in this paper , which leads to rapid...
Multifunctional nanostructures for intracellular delivery and sensing in electrogenic cells
TL;DR: In this article , a microfluidic multielectrode array (MEA) was used to record both spontaneous and chemically induced activity in vitro, and the adoption of nanoporous metamaterial in place of nanostructures might lower costs and speed up production.
References
More filters
Journal ArticleDOI
Electrochemical Methods: Fundamentals and Applications
TL;DR: In this paper, the authors present a survey of electrochemical methods and their applications, focusing on the following categories: electrochemical water treatment methods, electrochemical method fundamentals and applications, and student solutions manual.
Journal ArticleDOI
Application of conducting polymers to biosensors.
TL;DR: In the present review an attempt has been made to describe the salient features of conducting polymers and their wide applications in health care, food industries, environmental monitoring etc.
Journal ArticleDOI
Stimulation of neurite outgrowth using an electrically conducting polymer
TL;DR: The electrically conductive polymer--oxidized polypyrrole (PP)--has been evaluated for use as a substrate to enhance nerve cell interactions in culture as a first step toward potentially using such polymers to stimulate in vivo nerve regeneration.
Journal ArticleDOI
Retinal Repair by Transplantation of Photoreceptor Precursors
Robert E MacLaren,Rachael A. Pearson,A MacNeil,Ronald H. Douglas,Thomas E. Salt,Masayuki Akimoto,Anand Swaroop,Jane C. Sowden,Robin R. Ali +8 more
TL;DR: It is shown that donor cells can integrate into the adult or degenerating retina if they are taken from the developing retina at a time coincident with the peak of rod genesis, and the ontogenetic stage of donor cells for successful rod photoreceptor transplantation is defined.
Journal ArticleDOI
Subretinal electronic chips allow blind patients to read letters and combine them to words
Eberhart Zrenner,Karl Ulrich Bartz-Schmidt,H. Benav,Dorothea Besch,A. Bruckmann,Veit-Peter Gabel,Florian Gekeler,Udo Greppmaier,Alex Harscher,Steffen Kibbel,Johannes Koch,Akos Kusnyerik,Akos Kusnyerik,Tobias Peters,Katarina Stingl,Helmut G. Sachs,Alfred Stett,Peter Szurman,Barbara Wilhelm,Robert Wilke +19 more
TL;DR: These results demonstrate for the first time that subretinal micro-electrode arrays with 1500 photodiodes can create detailed meaningful visual perception in previously blind individuals.
Related Papers (5)
A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness
José Fernando Maya-Vetencourt,Diego Ghezzi,Diego Ghezzi,Maria Rosa Antognazza,Elisabetta Colombo,Maurizio Mete,Paul Feyen,Andrea Desii,Ambra Buschiazzo,Mattia Di Paolo,Stefano Di Marco,Flavia Ticconi,Laura Emionite,Dmytro Shmal,Cecilia Marini,Ilaria Donelli,Giuliano Freddi,Rita Maccarone,Silvia Bisti,Gianmario Sambuceti,Grazia Pertile,Guglielmo Lanzani,Fabio Benfenati,Fabio Benfenati +23 more