A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Diego Ghezzi,Maria Rosa Antognazza,Rita Maccarone,Sebastiano Bellani,Sebastiano Bellani,Erica Lanzarini,Nicola Martino,Nicola Martino,Maurizio Mete,Grazia Pertile,Silvia Bisti,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati +13 more
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TLDR
It is demonstrated that this bio-organic interface restored light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration, suggesting that all-organic devices may play an important future role in sub-retinal prosthetic implants.Abstract:
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with lightinduced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants.read more
Citations
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Journal ArticleDOI
Photoactive Poly(3-hexylthiophene) Nanoweb for Optoelectrical Stimulation to Enhance Neurogenesis of Human Stem Cells.
Kisuk Yang,Jin Young Oh,Jong Seung Lee,Yoonhee Jin,Gyeong Eon Chang,Soo Sang Chae,Eunji Cheong,Hong Koo Baik,Seung Woo Cho +8 more
TL;DR: The photoactive nanoweb substrates developed in this study may serve as platforms for producing stem cell therapeutics with enhanced neurogenesis and neuromodulation via optoelectrical control of stem cells.
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Integration of a silk fibroin based film as a luminescent down-shifting layer in ITO-free organic solar cells
Mario Prosa,Anna Sagnella,Tamara Posati,Marta Tessarolo,Margherita Bolognesi,Susanna Cavallini,Stefano Toffanin,Valentina Benfenati,Mirko Seri,Giampiero Ruani,Michele Muccini,Roberto Zamboni +11 more
TL;DR: In this paper, the integration of the silk fibroin (SF) protein in organic solar cells was reported, where water stable, optically transparent, smooth and homogeneous SF thin films (thickness ∼400 nm) were successfully prepared on glass and characterized.
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Photoelectrochemical TiO2‐Au‐Nanowire‐Based Motor for Precise Modulation of Single‐Neuron Activities
Bin Chen,Bin Chen,Lu Liu,Kun Liu,Fei Tong,Shuanghu Wang,Dongmei Fu,Junbin Gao,Jiamiao Jiang,Juanfeng Ou,Yicheng Ye,Daniela A. Wilson,Yingfeng Tu,Fei Peng +13 more
TL;DR: This is the first study to report on the photoelectric conversion capabilities of a motor being used to provide propulsion force and interactive cues in a biosystem, and represents a new approach for the precise and non‐invasive delivery of bioelectrical signals and neuronal activity modulation.
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Conjugated Polymer for Implantable Electronics toward Clinical Application.
TL;DR: In this paper, a review article summarizes the latest advances in implantable electronics using conjugated polymers as electroactive materials and identifies remaining challenges and opportunities for developing electronic medicine.
Journal ArticleDOI
Field-effect and capacitive properties of water-gated transistors based on polythiophene derivatives
Rossella Porrazzo,Rossella Porrazzo,Sebastiano Bellani,Sebastiano Bellani,Alessandro Luzio,Chiara Bertarelli,Chiara Bertarelli,Guglielmo Lanzani,Guglielmo Lanzani,Mario Caironi,Maria Rosa Antognazza +10 more
TL;DR: In this paper, a series of polythiophene derivatives, presenting different alkyl side chains lengths and orientation, and characterized by various morphologies, were systematically explored, and a comparative evaluation of their performances allowed highlighting the critical role played by alkyal side chains, which significantly affects the polymer/water interface capacitance.
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