A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Diego Ghezzi,Maria Rosa Antognazza,Rita Maccarone,Sebastiano Bellani,Sebastiano Bellani,Erica Lanzarini,Nicola Martino,Nicola Martino,Maurizio Mete,Grazia Pertile,Silvia Bisti,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati +13 more
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TLDR
It is demonstrated that this bio-organic interface restored light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration, suggesting that all-organic devices may play an important future role in sub-retinal prosthetic implants.Abstract:
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with lightinduced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants.read more
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Numerical methods for organic optoelectronic devices: simulations and experiments
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Monitoring fluorescent calcium signals in neural cells with organic photodetectors
Shahab Rezaei-Mazinani,Anton Ivanov,Markus Biele,Alexandra L. Rutz,Vasilis G. Gregoriou,Apostolos Avgeropoulos,Sandro Francesco Tedde,Christos L. Chochos,Christophe Bernard,Rodney P. O'Connor,George G. Malliaras,Esma Ismailova +11 more
TL;DR: In this paper, a simple-structure organic photodetector (OPD) was fabricated in open-air, with an active layer consisting of eXtra Large bandgap Polymer (XPL) blended with fullerene.
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Tailored polymeric, photovoltaic, and near-infrared-responsive neuroprosthesis
Marta Jole Ildelfonsa Airaghi Leccardi,Naïg Aurelia Ludmilla Chenais,Laura Ferlauto,Maciej Kawecki,Elodie Geneviève Zollinger,Diego Ghezzi +5 more
TL;DR: A new photovoltaic organic interface tailored for neuronal stimulation in the near-infrared spectrum is shown and it is shown that this interface provides an efficient, reliable, and stable implant applicable for neural stimulation.
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Optical Control of Living Cells Electrical Activity by Conjugated Polymers.
Nicola Martino,Caterina Bossio,Susana Vaquero Morata,Guglielmo Lanzani,Guglielmo Lanzani,Maria Rosa Antognazza +5 more
TL;DR: It is shown that both depolarizing and hyperpolarizing effects on the cell membrane can be achieved depending on the duration of the light stimulus, and this work describes a new approach for optical modulation of cellular activity.
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Bio-interface behaviour of graphene and semiconducting SWCNT:C60 blend based nano photodiode for subretinal implant
TL;DR: The improved electrical performance of graphene, S-SWCNT:C60 established in the previous studies and the excellent bio-interface performance of this nano photodiode shows that the nano Photodiode array proposed by the authors is a strong candidate for subretinal implants.
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