A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Diego Ghezzi,Maria Rosa Antognazza,Rita Maccarone,Sebastiano Bellani,Sebastiano Bellani,Erica Lanzarini,Nicola Martino,Nicola Martino,Maurizio Mete,Grazia Pertile,Silvia Bisti,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati +13 more
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TLDR
It is demonstrated that this bio-organic interface restored light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration, suggesting that all-organic devices may play an important future role in sub-retinal prosthetic implants.Abstract:
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with lightinduced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants.read more
Citations
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Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve.
Vivien Gaillet,Annarita Cutrone,Fiorenzo Artoni,Fiorenzo Artoni,Paola Vagni,Ariastity Mega Pratiwi,Sandra Alejandra Romero,Dario Lipucci Di Paola,Silvestro Micera,Silvestro Micera,Diego Ghezzi +10 more
TL;DR: It is shown, in anaesthetized rabbits and with support from numerical modelling, that an intraneural electrode array with high mechanical stability placed in the intracranial segment of the optic nerve induces, on electrical stimulation, selective activation patterns in the visual cortex.
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Improving mobility and electrochemical stability of a water-gated polymer field-effect transistor
Rossella Porrazzo,Rossella Porrazzo,Sebastiano Bellani,Sebastiano Bellani,Alessandro Luzio,Erica Lanzarini,Mario Caironi,Maria Rosa Antognazza +7 more
TL;DR: In this article, a water-gated polymer-based organic field effect transistors using poly(2,5-bis(3-hexadecylthiophen-2-yl)thieno[3,2- b ]thiophene) (pBTTT) is presented.
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Surface Polarization Drives Photoinduced Charge Separation at the P3HT/Water Interface
Edoardo Mosconi,Paolo Salvatori,Maria Ilenia Saba,Alessandro Mattoni,Sebastiano Bellani,Sebastiano Bellani,Francesco Bruni,Beatriz Santiago Gonzalez,Maria Rosa Antognazza,Sergio Brovelli,Guglielmo Lanzani,Guglielmo Lanzani,Hong Li,Jean-Luc Brédas,Filippo De Angelis +14 more
TL;DR: In this paper, the authors investigated the interfacial electronic structure of poly-3-hexylthiophene (P3HT) sandwiched between an indium tin oxide (ITO) electrode and a liquid water electrolyte.
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Nanoparticles: A Challenging Vehicle for Neural Stimulation
Elisabetta Colombo,Paul Feyen,Maria Rosa Antognazza,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati,Fabio Benfenati +6 more
TL;DR: This mini-review focuses on the employment of nanoparticles for the modulation of the electrophysiological activity of neuronal networks and the related transduction mechanisms underlying the nanostructure-neuron interfaces.
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Cellular interfaces with hydrogen-bonded organic semiconductor hierarchical nanocrystals.
Mykhailo Sytnyk,Marie Jakešová,Marie Jakešová,Monika Litviňuková,Oleksandr Mashkov,Dominik Kriegner,Julian Stangl,Jana Nebesářová,Frank W. Fecher,Wolfgang Schöfberger,Niyazi Serdar Sariciftci,Rainer Schindl,Rainer Schindl,Wolfgang Heiss,Eric Daniel Głowacki,Eric Daniel Głowacki +15 more
TL;DR: Hedgehog-shaped crystals comprising nanoscale needles or daggers that form intimate interfaces with the cell membrane, minimising the cleft with single cells without apparent detriment to viability are photostimulated.
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