A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Diego Ghezzi,Maria Rosa Antognazza,Rita Maccarone,Sebastiano Bellani,Sebastiano Bellani,Erica Lanzarini,Nicola Martino,Nicola Martino,Maurizio Mete,Grazia Pertile,Silvia Bisti,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati +13 more
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TLDR
It is demonstrated that this bio-organic interface restored light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration, suggesting that all-organic devices may play an important future role in sub-retinal prosthetic implants.Abstract:
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with lightinduced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants.read more
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References
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Journal ArticleDOI
A hybrid bioorganic interface for neuronal photoactivation
Diego Ghezzi,Maria Rosa Antognazza,Marco Dal Maschio,Erica Lanzarini,Erica Lanzarini,Fabio Benfenati,Guglielmo Lanzani,Guglielmo Lanzani +7 more
TL;DR: It is shown that primary neurons can be successfully grown onto the polymer layer without affecting the optoelectronic properties of the active material or the biological functionality of neuronal network, and action potentials can be triggered in a temporally reliable and spatially selective manner with short pulses of visible light.
Journal ArticleDOI
Photochemical Restoration of Visual Responses in Blind Mice
Aleksandra Polosukhina,Jeffrey Litt,Ivan Tochitsky,Joseph P. Nemargut,Yivgeny Sychev,Ivan De Kouchkovsky,Tracy Huang,Katharine Borges,Dirk Trauner,Russell N. Van Gelder,Richard H. Kramer +10 more
TL;DR: It is shown that AAQ, a synthetic small molecule photoswitch, can restore light sensitivity to the retina and behavioral responses in vivo in mouse models of RP, without exogenous gene delivery.
Journal ArticleDOI
Optogenetics: controlling cell function with light
TL;DR: A brief description of the basic steps required to control cellular function with optogenetics is presented.
Journal ArticleDOI
Nanoscale engineering of a cellular interface with semiconductor nanoparticle films for photoelectric stimulation of neurons.
Todd C. Pappas,W. M Shan Wickramanyake,Edward Jan,Massoud Motamedi,Malcolm S. Brodwick,Nicholas A. Kotov +5 more
TL;DR: This study reports the first example of hybrid bionanodevice where absorption of light by thin films of quantum confined semiconductor nanoparticles of HgTe produced by the layer-by-layer assembly stimulate adherent neural cells via a sequence of photochemical and charge-transfer reactions.
Journal ArticleDOI
Flexible, all-polymer microelectrode arrays for the capture of cardiac and neuronal signals.
Axel Blau,Angelika Murr,Sandra Wolff,Evelyne Sernagor,Paolo Medini,Giuliano Iurilli,Christiane Ziegler,Fabio Benfenati +7 more
TL;DR: The bendable, somewhat stretchable, non-cytotoxic and biostable all-polymer microelectrode arrays (polyMEAs) with a thickness below 500 μm and up to 60 electrodes reliably capture action potentials and local field potentials from acute preparations of heart muscle cells and retinal whole mounts, in vivo epicortical and epidural recordings as well as during long-term in vitro recordings from cortico-hippocampal co-cultures.
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