A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Diego Ghezzi,Maria Rosa Antognazza,Rita Maccarone,Sebastiano Bellani,Sebastiano Bellani,Erica Lanzarini,Nicola Martino,Nicola Martino,Maurizio Mete,Grazia Pertile,Silvia Bisti,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati +13 more
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TLDR
It is demonstrated that this bio-organic interface restored light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration, suggesting that all-organic devices may play an important future role in sub-retinal prosthetic implants.Abstract:
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with lightinduced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants.read more
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Design Parameters and Human Biocompatibility Assessment Protocols for Organic Semiconducting Neural Interfaces: Toward a Printed Artificial Retina with Color Vision
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References
More filters
Journal ArticleDOI
Electrochemical Methods: Fundamentals and Applications
TL;DR: In this paper, the authors present a survey of electrochemical methods and their applications, focusing on the following categories: electrochemical water treatment methods, electrochemical method fundamentals and applications, and student solutions manual.
Journal ArticleDOI
Application of conducting polymers to biosensors.
TL;DR: In the present review an attempt has been made to describe the salient features of conducting polymers and their wide applications in health care, food industries, environmental monitoring etc.
Journal ArticleDOI
Stimulation of neurite outgrowth using an electrically conducting polymer
TL;DR: The electrically conductive polymer--oxidized polypyrrole (PP)--has been evaluated for use as a substrate to enhance nerve cell interactions in culture as a first step toward potentially using such polymers to stimulate in vivo nerve regeneration.
Journal ArticleDOI
Retinal Repair by Transplantation of Photoreceptor Precursors
Robert E MacLaren,Rachael A. Pearson,A MacNeil,Ronald H. Douglas,Thomas E. Salt,Masayuki Akimoto,Anand Swaroop,Jane C. Sowden,Robin R. Ali +8 more
TL;DR: It is shown that donor cells can integrate into the adult or degenerating retina if they are taken from the developing retina at a time coincident with the peak of rod genesis, and the ontogenetic stage of donor cells for successful rod photoreceptor transplantation is defined.
Journal ArticleDOI
Subretinal electronic chips allow blind patients to read letters and combine them to words
Eberhart Zrenner,Karl Ulrich Bartz-Schmidt,H. Benav,Dorothea Besch,A. Bruckmann,Veit-Peter Gabel,Florian Gekeler,Udo Greppmaier,Alex Harscher,Steffen Kibbel,Johannes Koch,Akos Kusnyerik,Akos Kusnyerik,Tobias Peters,Katarina Stingl,Helmut G. Sachs,Alfred Stett,Peter Szurman,Barbara Wilhelm,Robert Wilke +19 more
TL;DR: These results demonstrate for the first time that subretinal micro-electrode arrays with 1500 photodiodes can create detailed meaningful visual perception in previously blind individuals.
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