A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Diego Ghezzi,Maria Rosa Antognazza,Rita Maccarone,Sebastiano Bellani,Sebastiano Bellani,Erica Lanzarini,Nicola Martino,Nicola Martino,Maurizio Mete,Grazia Pertile,Silvia Bisti,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati +13 more
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TLDR
It is demonstrated that this bio-organic interface restored light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration, suggesting that all-organic devices may play an important future role in sub-retinal prosthetic implants.Abstract:
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with lightinduced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants.read more
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Organic semiconductors for artificial vision
Nicola Martino,Nicola Martino,Diego Ghezzi,Fabio Benfenati,Guglielmo Lanzani,Guglielmo Lanzani,Maria Rosa Antognazza +6 more
TL;DR: This work has shown that organic-based devices for image detection, taking advantage of typical features of natural visual systems, such as trichromatic sensing, can be interfaced with biological tissues for cell photo-stimulation and restored light sensitivity in the case of retinas affected by photoreceptor degeneration.
Journal ArticleDOI
Nanowire arrays restore vision in blind mice
Jing Tang,Nan Qin,Yan Chong,Yupu Diao,Yiliguma,Zhexuan Wang,Tian Xue,Min Jiang,Jiayi Zhang,Gengfeng Zheng +9 more
TL;DR: Gold-titania nanowire arrays that restore visual response in blind mice are developed and will shed light on the development of a new generation of optoelectronic toolkits for subretinal prosthetic devices.
Journal ArticleDOI
Light-evoked hyperpolarization and silencing of neurons by conjugated polymers
Paul Feyen,Elisabetta Colombo,Duco Endeman,Mattia Nova,Lucia Laudato,Nicola Martino,Nicola Martino,Maria Rosa Antognazza,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati,Fabio Benfenati,Diego Ghezzi +12 more
TL;DR: The use of conjugated polymer films interfaced with neurons for inducing a light-mediated inhibition of their electrical activity triggers a sustained hyperpolarization of the neuronal membrane that significantly reduces both spontaneous and evoked action potential firing.
Journal ArticleDOI
Optoelectronic control of single cells using organic photocapacitors.
Marie Jakešová,Malin Silverå Ejneby,Vedran Đerek,Tony Schmidt,Maciej Gryszel,Johan Brask,Rainer Schindl,Daniel Simon,Magnus Berggren,Fredrik Elinder,Eric Daniel Głowacki +10 more
TL;DR: The results demonstrate that the OEPC can be a versatile nongenetic technique for optical manipulation of electrophysiology and currently represents one of the simplest and most stable and efficient optical stimulation solutions.
Journal ArticleDOI
Retinal prostheses: progress toward the next generation implants
TL;DR: This review is focused on critically discussing recent major advancements in the field of retinal stimulation with particular attention to the findings in the application of novel concepts and materials.
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