A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Diego Ghezzi,Maria Rosa Antognazza,Rita Maccarone,Sebastiano Bellani,Sebastiano Bellani,Erica Lanzarini,Nicola Martino,Nicola Martino,Maurizio Mete,Grazia Pertile,Silvia Bisti,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati +13 more
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TLDR
It is demonstrated that this bio-organic interface restored light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration, suggesting that all-organic devices may play an important future role in sub-retinal prosthetic implants.Abstract:
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with lightinduced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants.read more
Citations
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Neuronal firing modulation by a membrane-targeted photoswitch
Mattia L. DiFrancesco,Francesco Lodola,Elisabetta Colombo,Luca Maragliano,Mattia Bramini,Mattia Bramini,Giuseppe M. Paternò,Pietro Baldelli,Mauro Dalla Serra,Lorenzo Lunelli,Marta Marchioretto,Giorgio Grasselli,Simone Cimò,Simone Cimò,Letizia Colella,Daniele Fazzi,Fausto Ortica,Vito Vurro,Cyril G. Eleftheriou,Cyril G. Eleftheriou,Dmytro Shmal,José Fernando Maya-Vetencourt,José Fernando Maya-Vetencourt,Chiara Bertarelli,Chiara Bertarelli,Guglielmo Lanzani,Fabio Benfenati +26 more
TL;DR: It is demonstrated that in neurons loaded with the Ziapin2 compound, millisecond pulses of visible light induce a transient hyperpolarization followed by a delayed depolarization that triggers action potential firing and these effects are persistent and can be evoked in vivo up to 7 days, proving the potential of ZiAPin2 for the modulation of membrane capacitance in the millisecond timescale.
Journal ArticleDOI
Near-Infrared Tandem Organic Photodiodes for Future Application in Artificial Retinal Implants
Giulio Simone,Dario Di Carlo Rasi,Xander de Vries,Gaël H. L. Heintges,Stefan C. J. Meskers,René A. J. Janssen,Gerwin H. Gelinck +6 more
TL;DR: Organic photodiodes sensitive to near‐infrared (NIR) light are evaluated as photovoltaic pixels for future application in retinal prostheses and only tandem OPD pixels can cover the entire charge per pulse neural stimulation window due to their higher V OC.
Journal ArticleDOI
Solution-processed two-dimensional materials for next-generation photovoltaics
Sebastiano Bellani,Antonino Bartolotta,Antonio Agresti,Giuseppe Calogero,Giulia Grancini,Aldo Di Carlo,Aldo Di Carlo,Emmanuel Kymakis,Francesco Bonaccorso +8 more
TL;DR: In this article, a review of the use of solution-processed 2D materials in organic solar cells, dye-sensitized solar cells and perovskite solar cells is presented.
Journal ArticleDOI
Semiconducting polymers are light nanotransducers in eyeless animals
Claudia Tortiglione,Maria Rosa Antognazza,Angela Tino,Caterina Bossio,Valentina Marchesano,Antonella Bauduin,Mattia Zangoli,Susana Vaquero Morata,Guglielmo Lanzani,Guglielmo Lanzani +9 more
TL;DR: It is shown that nanoparticles based on poly(3-hexylthiophene) can be internalized in eyeless freshwater polyps and are fully biocompatible, and suggests the establishment of a seamless and biomimetic interface between the living organism and the polymer nanoparticles that behave as light nanotransducers, coping with or amplifying the function of primitive photoreceptors.
Journal ArticleDOI
Photostimulation of Whole-Cell Conductance in Primary Rat Neocortical Astrocytes Mediated by Organic Semiconducting Thin Films
Valentina Benfenati,Nicola Martino,Nicola Martino,Maria Rosa Antognazza,Assunta Pistone,Stefano Toffanin,Stefano Ferroni,Guglielmo Lanzani,Guglielmo Lanzani,Michele Muccini +9 more
TL;DR: Biophysical and pharmacological characterization suggests that the ion channel mediating the photo‐transduction mechanism is a chloride channel, the ClC‐2 channel, which opens interesting perspectives for the selective manipulation of astrocyte bioelectrical activity by non‐invasive, label‐free, organic‐based, photostimulation approaches.
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