A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Diego Ghezzi,Maria Rosa Antognazza,Rita Maccarone,Sebastiano Bellani,Sebastiano Bellani,Erica Lanzarini,Nicola Martino,Nicola Martino,Maurizio Mete,Grazia Pertile,Silvia Bisti,Guglielmo Lanzani,Guglielmo Lanzani,Fabio Benfenati +13 more
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TLDR
It is demonstrated that this bio-organic interface restored light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration, suggesting that all-organic devices may play an important future role in sub-retinal prosthetic implants.Abstract:
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with lightinduced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants.read more
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Conjugated polymers for the optical control of the electrical activity of living cells
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TL;DR: Four different conjugated polymers, regarded as prototypes of their category, are investigated as photoactive bio-interfaces and it is demonstrated that all considered polymers are characterized by good biocompatibility and cell seeding properties, and can optimally sustain thermal sterilization.
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Photoconductive Micro/Nanoscale Interfaces of a Semiconducting Polymer for Wireless Stimulation of Neuron-Like Cells.
Yingjie Wu,Yanfen Peng,Hassan Bohra,Jianping Zou,Vivek Damodar Ranjan,Yilei Zhang,Qing Zhang,Mingfeng Wang +7 more
TL;DR: This work reports multiscale structured fibers and patterned films based on a semiconducting polymer, poly(3-hexylthiophene) (P3HT), as photoconductive biointerfaces to promote neuronal stimulation upon light irradiation and demonstrates that neurons on P3HT nanofibers showed a significantly higher total number of branches, while neurons grown on P2HT microfibers had longer and thinner neurites.
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Electroactive material-based biosensors for detection and drug delivery
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