A rapidly acquired foraging-based working memory task, sensitive to hippocampal lesions, reveals age-dependent and age-independent behavioural changes in a mouse model of amyloid pathology.

TLDR: Novel insight is provided into the role of the hippocampus and the effects of APP overexpression on memory and search behaviour in an open‐field foraging task in PDAPP mice.

About: This article is published in Neurobiology of Learning and Memory.The article was published on 2018-03-01 and is currently open access. It has received 7 citations till now. The article focuses on the topics: Working memory.

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Table 5. Table showing the mean (and SEM) of the number of perseverative errors and chaining responses in the foraging task made by HPC lesion mice (n=11) and SHAM controls (n=13; Experiment 1 and 2) and WT (n=15) and PDAPP mice (n=14; Experiment 3). Numbers in bold represent significant differences in between group comparisons.

Figure 3: Foraging behaviour in control mice and mice with HPC lesions. Measures of SWM in SHAM control (n=13) and HPC lesion mice (n=11). A) Total number of errors. B) Total number of repeat errors. C) The ratio of neighbouring and distal errors to total errors made. *p<0.05. Data were averaged across four trials for each mouse and mean score for each group is reported. Error bars represent the S.E.M.

Figure 2. Reconstruction of the minimal (A) and maximal (B) extent of bilateral hippocampal lesions through coronal sections through the brain. Coordinates represent distance from bregma in mm.

Figure 4: Foraging behaviour in mice with HPC lesions. Measures of SWM in SHAM control (n=13) and HPC lesion mice (n=11). A) Total number of errors. B) Total number of repeat errors. C) The ratio of neighbouring and distal errors to total errors made. **p<0.01. Data were averaged across four trials for each mouse and mean score for each group is reported. Error bars represent the S.E.M.

Figure 5: Foraging behaviour and SWM performance in PDAPP (n=14) and WT control mice (n=15). Data were averaged across four trials for each mouse and mean score for each group is reported. Error bars represent the S.E.M. A) Total number of errors. B) Total number of repeat errors. C) The ratio of neighbouring and distal errors to total errors made. *p<0.05