A rapidly acquired foraging-based working memory task, sensitive to hippocampal lesions, reveals age-dependent and age-independent behavioural changes in a mouse model of amyloid pathology.
TLDR
Novel insight is provided into the role of the hippocampus and the effects of APP overexpression on memory and search behaviour in an open‐field foraging task in PDAPP mice.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2018-03-01 and is currently open access. It has received 7 citations till now. The article focuses on the topics: Working memory.read more
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ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease
Charles E. Evans,James Scott Miners,Giulia Piva,Christine L. Willis,David M. Heard,Emma Jane Kidd,Mark Andrew Good,Patrick G. Kehoe +7 more
TL;DR: In this article, diminazene aceturate (DIZE), an established activator of ACE2, was shown to reduce hippocampal Aβ and restore cognition in mid-aged (13-14-month-old) symptomatic Tg2576 mice.
Journal ArticleDOI
The cognitive control of eating and body weight: it's more than what you "think"
TL;DR: Evidence is reviewed that consuming a WD is associated with the emergence of pathophysiologies in the hippocampus, an important brain substrate for learning, memory, and cognition, and how eating a WD could impair hippocampal function, producing cognitive deficits that promote increased WD intake and body weight gain.
Journal ArticleDOI
A positive allosteric modulator of mGluR5 promotes neuroprotective effects in mouse models of Alzheimer's disease.
Paula Maria Quaglio Bellozi,Giovanni Freitas Gomes,Maria Carolina Machado da Silva,Isabel Vieira de Assis Lima,Carla R.A. Batista,Wellerson de Oliveira Carneiro Junior,Juliana G. Doria,Érica Leandro Marciano Vieira,Rafael P. Vieira,Rossimiriam Pereira de Freitas,Cláudia N. Ferreira,Eduardo Candelario-Jalil,Tony Wyss-Coray,Fabiola M. Ribeiro,Antônio Carlos Pinheiro de Oliveira +14 more
TL;DR: Despite a four-week treatment did not prevent memory loss in aged transgenic mice, CDPPB possess is protective against Aβ stimulus, therefore, this drug represents a potential candidate for further investigations as AD treatment.
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Alzheimer's Disease Animal Models: Elucidation of Biomarkers and Therapeutic Approaches for Cognitive Impairment.
TL;DR: In this article, a review assesses several Alzheimer's disease mouse models from the aspect of biomarkers and cognitive impairment and discusses their potential as tools to provide novel AD therapeutic approaches, but none of these models exhibit all pathologies present in human AD.
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Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice.
Charles E. Evans,Rhian S. Thomas,Thomas J. Freeman,Martha Hvoslef-Eide,Mark Andrew Good,Emma Jane Kidd +5 more
TL;DR: An antibody, 2B3, is used that binds to APP at the BACE cleavage site, inhibiting Aβ production and improves memory for object-in-place associations and working memory in a foraging task in PDAPP mice and WT mice.
References
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The mechanisms for pattern completion and pattern separation in the hippocampus
TL;DR: The mechanisms for pattern completion and pattern separation are described in the context of a theory of hippocampal function in which the hippocampal CA3 system operates as a single attractor or autoassociation network to enable rapid, one-trial, associations between any spatial location and an object or reward.
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Working memory and executive function decline across normal aging, mild cognitive impairment, and Alzheimer's disease.
TL;DR: The present review tracks WM decline through normal aging, MCI, andAD to highlight the behavioral and neurological differences that distinguish these three stages in an effort to guide future research on MCI diagnosis, cognitive therapy, and AD prevention.
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Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease.
Michael H. Donovan,Umar Yazdani,Rebekah D. Norris,Dora Games,Dwight C. German,Amelia J. Eisch +5 more
TL;DR: An age‐dependent decrease in SGZ proliferation in homozygous PDAPP mice is reported, suggesting altered neurogenesis in the PDAPP mouse may contribute to the age‐related cognitive deficits reported in this model of AD and may be a useful adjunct target for assessing the impact of AD therapies.
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Selective hippocampal lesions and behavior: effects of kainic acid lesions on performance of place and cue tasks.
TL;DR: The presence of distant damage beyond the immediate area of injection complicates interpretation of the results and may serve to limit the usefulness of KA as a neurotoxin in behavioral investigations.
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Cues that hippocampal place cells encode: dynamic and hierarchical representation of local and distal stimuli.
TL;DR: The results show that hippocampal neurons encode a hierarchical representation of environmental information through the encoding of local and distal cues within a stimulus set.