A review of gene and stem cell therapy in cutaneous wound healing
TLDR
Gene therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair, and in order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential.About:
This article is published in Burns.The article was published on 2009-03-01 and is currently open access. It has received 278 citations till now. The article focuses on the topics: Stem-cell therapy & Stem cell transplantation for articular cartilage repair.read more
Citations
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Advanced Therapeutic Dressings for Effective Wound Healing—A Review
TL;DR: In this article, the current state of wound healing and wound management products, with emphasis on the demand for more advanced forms of wound therapy and some of the current challenges and driving forces behind this demand, are reviewed.
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Advances in skin grafting and treatment of cutaneous wounds.
TL;DR: The classic paradigms of wound healing are reviewed and how recent discoveries have enriched understanding of this process are evaluated, with an emphasis on cell-based therapies and skin transplantation.
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Dual growth factor releasing multi-functional nanofibers for wound healing
Zhiwei Xie,Christian B. Paras,Hong Weng,Primana Punnakitikashem,Lee Chun Su,Khanh Vu,Liping Tang,Jian Yang,Kytai T. Nguyen +8 more
TL;DR: A preliminary in vivo study performed on normal full thickness rat skin wound models demonstrated that nanofiber/nanoparticle scaffolds significantly accelerated the wound healing process by promoting angiogenesis, increasing re-epithelialization and controlling granulation tissue formation.
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Therapeutic strategies for enhancing angiogenesis in wound healing.
TL;DR: This review surveys the creation of new treatments for healing cutaneous wounds through therapeutic angiogenesis and discusses the challenges and advancement that have been made in delivering biologic, pharmaceutical and cell-based therapies as enhancers of wound vascularity and healing.
Book
Drug Delivery Systems: Advanced Technologies Potentially Applicable In Personalised Treatment
Jorge F. J. Coelho,Paula Ferreira,Paula Ferreira,Patrícia Alves,Rosemeyre A. Cordeiro,Ana Catarina R.G. Fonseca,Joana R. Góis,Maria H. Gil +7 more
TL;DR: General concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes) are described.
References
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc.
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Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
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Cutaneous wound healing.
TL;DR: The primary goals of the treatment of wounds are rapid wound closure and a functional and aesthetically satisfactory scar.
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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Manfred Gossen,Hermann Bujard +1 more
TL;DR: Control elements of the tetracycline-resistance operon encoded in Tn10 of Escherichia coli have been utilized to establish a highly efficient regulatory system in mammalian cells that is suitable for creation of "on/off" situations for such genes in a reversible way.