Acute Myeloid Leukemia, Version 2.2021 Featured Updates to the NCCN Guidelines
Daniel A. Pollyea,Dale L. Bixby,Alexander E. Perl,Vijaya Raj Bhatt,Jessica K. Altman,Frederick R. Appelbaum,Marcos de Lima,Amir T. Fathi,James M. Foran,Ivana Gojo,Aric C. Hall,Meagan A. Jacoby,Jeffrey E. Lancet,Gabriel N. Mannis,Guido Marcucci,Michael Gary Martin,Alice S. Mims,Jadee L. Neff,Reza Nejati,Rebecca L. Olin,Mary Elizabeth Percival,Thomas Prebet,Amanda Przespolewski,Dinesh S. Rao,Farhad Ravandi-Kashani,Paul J. Shami,Richard Stone,Stephen A. Strickland,Kendra Sweet,Pankit Vachhani,Matthew J. Wieduwilt,Kristina M. Gregory,Ndiya Ogba,Martin S. Tallman +33 more
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TLDR
The NCCN Guidelines for Acute Myeloid Leukemia (AML) provide recommendations for the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment, or have yielded new information regarding factors with prognostic importance, and are intended to aid physicians with clinical decision-making as mentioned in this paper.Abstract:
The NCCN Guidelines for Acute Myeloid Leukemia (AML) provide recommendations for the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment, or have yielded new information regarding factors with prognostic importance, and are intended to aid physicians with clinical decision-making. These NCCN Guidelines Insights focus on recent select updates to the NCCN Guidelines, including familial genetic alterations in AML, postinduction or postremission treatment strategies in low-risk acute promyelocytic leukemia or favorable-risk AML, principles surrounding the use of venetoclax-based therapies, and considerations for patients who prefer not to receive blood transfusions during treatment.read more
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Journal ArticleDOI
Diagnosis and Management of AML in Adults: 2022 ELN Recommendations from an International Expert Panel.
Hartmut Döhner,Andrew H. Wei,Frederick R. Appelbaum,Charles Craddock,Courtney D. DiNardo,Hervé Dombret,Benjamin L. Ebert,Pierre Fenaux,Lucy A. Godley,Robert P. Hasserjian,Richard A. Larson,Ross Levine,Yasushi Miyazaki,Dietger Niederwieser,Gert J. Ossenkoppele,Christoph Röllig,Jorge Sierra,Eytan M. Stein,Martin S. Tallman,Hwei-Fang Tien,Jianxiang Wang,Agnieszka Wierzbowska,Bob Löwenberg +22 more
TL;DR: This update includes a revised ELN genetic risk classification, revised response criteria, and treatment recommendations for acute myeloid leukemia in adults, which are widely recognized among physicians and investigators.
Journal ArticleDOI
Advances in acute myeloid leukemia
Laura F. Newell,Rachel J. Cook +1 more
TL;DR: A recent review as mentioned in this paper focuses on important updates in diagnostic and disease classifications that reflect new understanding of the biology of AML, its mutational heterogeneity, some important genetic and environmental risk factors, and new treatment options including cytotoxic chemotherapy, novel targeted agents, and cellular therapies.
Journal ArticleDOI
A review of FLT3 inhibitors in acute myeloid leukemia
TL;DR: Gilteritinib and midostaurin this paper have been used in the U.S. and Europe for newly diagnosed FLT3 mutated AML in combination with standard induction and consolidation chemotherapy.
Journal ArticleDOI
A review of FLT3 inhibitors in acute myeloid leukemia.
TL;DR: Gilteritinib and midostaurin this article have been used in the U.S. and Europe for newly diagnosed FLT3 mutated acute myeloid leukemia (AML) in combination with standard induction and consolidation chemotherapy.
Journal ArticleDOI
The Role of Tumor-Associated Macrophages in Hematologic Malignancies
TL;DR: A review of the role of TAM in different hematologic malignancies, focusing on the complex interplay between TAM and tumor cells, the prognostic value of TAM and the possible TAM-targeted therapeutic strategies is presented in this paper.
References
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The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia
Daniel A. Arber,Attilio Orazi,Robert P. Hasserjian,Jürgen Thiele,Michael J. Borowitz,Michelle M. Le Beau,Clara D. Bloomfield,Mario Cazzola,James W. Vardiman +8 more
TL;DR: The 2016 edition of the World Health Organization classification of tumors of the hematopoietic and lymphoid tissues represents a revision of the prior classification rather than an entirely new classification and attempts to incorporate new clinical, prognostic, morphologic, immunophenotypic, and genetic data that have emerged since the last edition.
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Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel
Hartmut Döhner,Elihu H. Estey,David Grimwade,Sergio Amadori,Frederick R. Appelbaum,Thomas Büchner,Hervé Dombret,Benjamin L. Ebert,Pierre Fenaux,Richard A. Larson,Ross L. Levine,Francesco Lo-Coco,Tomoki Naoe,Dietger Niederwieser,Gert J. Ossenkoppele,Miguel A. Sanz,Jorge Sierra,Martin S. Tallman,Hwei-Fang Tien,Andrew H. Wei,Andrew H. Wei,Bob Löwenberg,Clara D. Bloomfield +22 more
TL;DR: An international panel to provide updated evidence- and expert opinion-based recommendations for diagnosis and management of acute myeloid leukemia in adults includes a revised version of the ELN genetic categories, a proposal for a response category based on MRD status, and criteria for progressive disease.
Journal ArticleDOI
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
Timothy J. Ley,Christopher A. Miller,Li Ding,Benjamin J. Raphael,Andrew J. Mungall,Gordon Robertson,Katherine A. Hoadley,Timothy J. Triche,Peter W. Laird,Jack Baty,Lucinda Fulton,Robert S. Fulton,Sharon Heath,Joelle Kalicki-Veizer,Cyriac Kandoth,Jeffery M. Klco,Daniel C. Koboldt,Krishna L. Kanchi,Shashikant Kulkarni,Tamara Lamprecht,David E. Larson,G. Lin,Charles Lu,Michael D. McLellan,Joshua F. McMichael,Jacqueline E. Payton,Heather Schmidt,David H. Spencer,Michael H. Tomasson,John W. Wallis,Lukas D. Wartman,Mark A. Watson,John S. Welch,Michael C. Wendl,Adrian Ally,Miruna Balasundaram,Inanc Birol,Yaron S.N. Butterfield,Readman Chiu,Andy Chu,Eric Chuah,Hye Jung E. Chun,Richard Corbett,Noreen Dhalla,Ranabir Guin,An He,Carrie Hirst,Martin Hirst,Robert A. Holt,Steven J.M. Jones,Aly Karsan,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Karen Mungall,Jeremy Parker,Erin Pleasance,Patrick Plettner,Jacquie Schein,Dominik Stoll,Lucas Swanson,Angela Tam,Nina Thiessen,Richard Varhol,Natasja Wye,Yongjun Zhao,Stacey Gabriel,Gad Getz,Carrie Sougnez,Lihua Zou,Mark D.M. Leiserson,Fabio Vandin,Hsin-Ta Wu,Frederick Applebaum,Stephen B. Baylin,Rehan Akbani,Bradley M. Broom,Ken Chen,Thomas C. Motter,Khanh Thi-Thuy Nguyen,John N. Weinstein,Nianziang Zhang,Martin L. Ferguson,Christopher Adams,Aaron D. Black,Jay Bowen,Julie M. Gastier-Foster,Thomas Grossman,Tara M. Lichtenberg,Lisa Wise,Tanja Davidsen,John A. Demchok,Kenna R. Mills Shaw,Margi Sheth,Heidi J. Sofia,Liming Yang,James R. Downing,Greg Eley,Shelley Alonso,Brenda Ayala,Julien Baboud,Mark Backus,Sean P. Barletta,Dominique L. Berton,Anna L. Chu,Stanley Girshik,Mark A. Jensen,Ari B. Kahn,Prachi Kothiyal,Matthew C. Nicholls,Todd Pihl,David Pot,Rohini Raman,Rashmi N. Sanbhadti,Eric E. Snyder,Deepak Srinivasan,Jessica Walton,Yunhu Wan,Zhining Wang,Jean Pierre J. Issa,Michelle M. Le Beau,Martin Carroll,Hagop M. Kantarjian,Steven M. Kornblau,Moiz S. Bootwalla,Phillip H. Lai,Hui Shen,David Van Den Berg,Daniel J. Weisenberger,Daniel C. Link,Matthew J. Walter,Bradley A. Ozenberger,Elaine R. Mardis,Peter Westervelt,Timothy A. Graubert,John F. DiPersio,Richard K. Wilson +138 more
TL;DR: It is found that a complex interplay of genetic events contributes to AML pathogenesis in individual patients and the databases from this study are widely available to serve as a foundation for further investigations of AMl pathogenesis, classification, and risk stratification.
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Ries Lag,D. Harkins,Krapcho M,Angela B. Mariotto,Miller Ba,Eric J. Feuer,Limin X. Clegg,M. P. Eisner,Horner Mj,Nadia Howlader,Matthew J. Hayat,Benjamin F. Hankey,Brenda K. Edwards,Seer web site +13 more
Journal ArticleDOI
Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B
Robert J. Mayer,Roger B. Davis,Celia A. Schiffer,Deborah T. Berg,Bayard L. Powell,Philip Schulman,George A. Omura,Joseph O. Moore,O R McIntyre,Frei E rd +9 more
TL;DR: The concept of a dose-response effect for cytarabine in patients with AML who are 60 years of age or younger is supported and the results with the high-dose schedule in this age group are comparable to those reported in similar patients who have undergone allogeneic bone marrow transplantation during a first remission.
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Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel
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Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia
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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
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