Journal ArticleDOI
Advances in islet encapsulation technologies
Tejal A. Desai,Lonnie D. Shea +1 more
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TLDR
Although encapsulation technology has met several challenges, the convergence of expertise in materials, nanotechnology, stem cell biology and immunology is allowing the goal of encapsulated islet cell therapy for humans to be closer.Abstract:
Type 1 diabetes is an autoimmune disorder in which the immune system attacks and destroys insulin-producing islet cells of the pancreas. Although islet transplantation has proved to be successful for some patients with type 1 diabetes, its widespread use is limited by islet donor shortage and the requirement for lifelong immunosuppression. An encapsulation strategy that can prevent the rejection of xenogeneic islets or of stem cell-derived allogeneic islets can potentially eliminate both of these barriers. Although encapsulation technology has met several challenges, the convergence of expertise in materials, nanotechnology, stem cell biology and immunology is allowing us to get closer to the goal of encapsulated islet cell therapy for humans.read more
Citations
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Journal ArticleDOI
Engineered Biomaterials for Enhanced Function of Insulin-Secreting β-Cell Organoids
TL;DR: Improved function and maturation of β‐cell organoids will likely lead to improved transplant outcomes, but will also enable better models for physiology, disease modeling, and toxicology studies for type 1 and type 2 diabetes mellitus.
Journal ArticleDOI
Engineering Strategies to Improve Islet Transplantation for Type 1 Diabetes Therapy.
Alisa M White,James G. Shamul,Jiangsheng Xu,Samantha Stewart,Jonathan S. Bromberg,Xiaoming He,Xiaoming He +6 more
TL;DR: Overall, islet-laden capsule transplantation has greatly improved over the past 30 years and is moving towards becoming a clinically feasible treatment for type 1 diabetes.
Journal ArticleDOI
Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes
TL;DR: By understanding the advantages and disadvantages of materials from different sources and types, appropriate materials and encapsuling methods can be designed and selected as needed to improve the efficacy and duration of islet.
Journal ArticleDOI
Nanotechnology Approaches to Modulate Immune Responses to Cell-based Therapies for Type 1 Diabetes.
TL;DR: The applications of nanotechnology to advance the clinical potential of islet transplantation are discussed, with a focus on cell surface engineering, bioactive functionalization, and use of nanoparticles in T1D cell-based treatments.
Journal ArticleDOI
Designing biomaterials for the modulation of allogeneic and autoimmune responses to cellular implants in Type 1 Diabetes.
TL;DR: In this paper, the authors highlight the capacity of biomaterials to provide local and nuanced instruction to suppress or alter immune pathways activated in response to an allogeneic islet transplant.
References
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Journal ArticleDOI
Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen
A. M. J. Shapiro,Jonathan R. T. Lakey,Edmond A. Ryan,Gregory S. Korbutt,Ellen L. Toth,Garth L. Warnock,Norman M. Kneteman,Ray V. Rajotte +7 more
TL;DR: The observations in patients with type 1 diabetes indicate that islet transplantation can result in insulin independence with excellent metabolic control when glucocorticoid-free immunosuppression is combined with the infusion of an adequate islet mass.
Book
Introduction to protein structure
Carl Ivar Branden,John Tooze +1 more
TL;DR: Part 1 BASIC STRUCTURAL PRINCIPLES: The Building Blocks and Motifs of Protein Structure and Part 2 STRUCTURE, FUNCTION and ENGINEERING: Structure, Function and Engineering.
Journal ArticleDOI
Mesenchymal stem cells in health and disease
TL;DR: The targets and mechanisms of M SC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches are discussed.
Journal ArticleDOI
Macrophage activation and polarization.
TL;DR: The main functions of polarized macrophages are reviewed and the perspectives of this field are discussed, which include high endocytic clearance capacities and trophic factor synthesis, accompanied by reduced pro-inflammatory cytokine secretion.
Journal ArticleDOI
Microencapsulated islets as bioartificial endocrine pancreas
Franklin Lim,Anthony M. Sun +1 more
TL;DR: The microencapsulated islets remained morphologically and functionally intact throughout long-term culture studies lasting over 15 weeks.
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