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Journal ArticleDOI

Advances in islet encapsulation technologies

Tejal A. Desai, +1 more
- 01 May 2017 - 
- Vol. 16, Iss: 5, pp 338-350
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TLDR
Although encapsulation technology has met several challenges, the convergence of expertise in materials, nanotechnology, stem cell biology and immunology is allowing the goal of encapsulated islet cell therapy for humans to be closer.
Abstract: 
Type 1 diabetes is an autoimmune disorder in which the immune system attacks and destroys insulin-producing islet cells of the pancreas. Although islet transplantation has proved to be successful for some patients with type 1 diabetes, its widespread use is limited by islet donor shortage and the requirement for lifelong immunosuppression. An encapsulation strategy that can prevent the rejection of xenogeneic islets or of stem cell-derived allogeneic islets can potentially eliminate both of these barriers. Although encapsulation technology has met several challenges, the convergence of expertise in materials, nanotechnology, stem cell biology and immunology is allowing us to get closer to the goal of encapsulated islet cell therapy for humans.

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3D printing of hydrogels: Rational design strategies and emerging biomedical applications

Jinhua Li, +3 more
- 01 Apr 2020 - 
TL;DR: A review of hydrogel-based biomaterial inks and bioinks for 3D printing can be found in this paper, where the authors provide a comprehensive overview and discussion of the tailorability of material, mechanical, physical, chemical and biological properties.
Journal ArticleDOI

Non-invasive delivery strategies for biologics.

Aaron C. Anselmo, +2 more
- 01 Jan 2019 - 
TL;DR: This Review summarizes the current status, latest updates and future prospects for delivery of peptides, proteins and other biologics, including subcutaneous, transdermal, oral, inhalation, nasal and buccal routes.
Journal ArticleDOI

Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery

Miléna Lengyel, +4 more
- 09 Aug 2019 - 
TL;DR: The article presents the most important structures of microparticles (microspheres, microcapsules, coated pellets, etc.), interpreted with microscopic images too, as well as the drug release mechanisms and commonly used excipients.
Journal ArticleDOI

Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques.

Matthew A. Bochenek, +37 more
- 13 Aug 2018 - 
TL;DR: Transplantation of pancreatic islet cells encapsulated in alginate microspheres into the omental bursa of the peritoneal cavity of NHPs significantly reduces FBRs and extends the longevity of the cells.
Journal ArticleDOI

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges

Julie B. Sneddon, +6 more
- 01 Jun 2018 - 
TL;DR: Current efforts aimed at generating a sustainable source of functional human stem cell-derived insulin-producing islet cells for cell transplantation are described and state-of-the-art efforts to protect such cells via immune modulation and encapsulation strategies are presented.
References
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Journal ArticleDOI

Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape

Kaitlyn Kirk, +6 more
- 01 May 2014 - 
TL;DR: Monitoring human insulin secretion and bioluminescent imaging revealed for the first time that hESCs remained fully contained in encapsulation devices for up to 150 days, the longest period tested, suggest that encapsulated hESC derived islet progenitors hold great promise as an effective and safe cell replacement therapy for insulin dependent diabetes.
Journal ArticleDOI

Improved vascularization of planar membrane diffusion devices following continuous infusion of vascular endothelial growth factor.

Nitin Trivedi, +4 more
- 01 Jan 2000 - 
TL;DR: Vascular endothelial growth factor can be used to improve blood vessel formation adjacent to planar membrane diffusion devices, as well as other factors, as needed to improve the survival of encapsulated tissue.
Journal ArticleDOI

Survival of microencapsulated adult pig islets in mice in spite of an antibody response.

Valérie F. Duvivier-Kali, +6 more
- 01 Dec 2004 - 
TL;DR: Alginate capsules can prolong the survival of adult pig islets transplanted into diabetic mice for up to 190 days, even in the presence of an antibody response.
Journal ArticleDOI

Neural stem/progenitor cells modulate immune responses by suppressing T lymphocytes with nitric oxide and prostaglandin E2.

Lei Wang, +8 more
- 01 Mar 2009 - 
TL;DR: NSCs appear to suppress T-cells, at least in part, by NO and PGE2 production which, in turn, would account for the well-documented reduction of central nervous system immunopathology by transplanted NSCs.
Journal ArticleDOI

Improvement of subcutaneous bioartificial pancreas vascularization and function by coencapsulation of pig islets and mesenchymal stem cells in primates.

Sophie Vériter, +8 more
- 01 Nov 2014 - 
TL;DR: The cotransplantation of islets with MSCs improves only slightly the long-term function of a subcutaneous bioartificial pancreas in a primate preclinical model, but improves implant oxygenation and neoangiogenesis.
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