Journal ArticleDOI
Advances in islet encapsulation technologies
Tejal A. Desai,Lonnie D. Shea +1 more
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TLDR
Although encapsulation technology has met several challenges, the convergence of expertise in materials, nanotechnology, stem cell biology and immunology is allowing the goal of encapsulated islet cell therapy for humans to be closer.Abstract:
Type 1 diabetes is an autoimmune disorder in which the immune system attacks and destroys insulin-producing islet cells of the pancreas. Although islet transplantation has proved to be successful for some patients with type 1 diabetes, its widespread use is limited by islet donor shortage and the requirement for lifelong immunosuppression. An encapsulation strategy that can prevent the rejection of xenogeneic islets or of stem cell-derived allogeneic islets can potentially eliminate both of these barriers. Although encapsulation technology has met several challenges, the convergence of expertise in materials, nanotechnology, stem cell biology and immunology is allowing us to get closer to the goal of encapsulated islet cell therapy for humans.read more
Citations
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Domesticating the foreign body response: Recent advances and applications
Omid Veiseh,Arturo J. Vegas +1 more
TL;DR: Current mechanistic understanding of the foreign body response is reviewed and new anti-FBR technologies from this decade that have been applied successfully in biomedical applications relevant to implants, devices, and cell-based therapies are highlighted.
Journal ArticleDOI
3D cell printing of islet-laden pancreatic tissue-derived extracellular matrix bioink constructs for enhancing pancreatic functions
Jaewook Kim,In Kyong Shim,Dong Gyu Hwang,Yu Na Lee,Myungji Kim,Hyeonji Kim,Seok-Won Kim,Song Lee,Song Cheol Kim,Dong-Woo Cho,Jinah Jang +10 more
TL;DR: This study validated the possibility of fabricating 3D constructs of a therapeutically applicable transplant size that can potentially be an allogeneic source of islets, such as patient-induced pluripotent stem cell-derived insulin-producing cells.
Journal ArticleDOI
In vivo reprogramming of immune cells: Technologies for induction of antigen-specific tolerance
TL;DR: This review describes natural mechanisms of peripheral tolerance induction and the various technologies being developed to achieve antigen‐specific immune tolerance in vivo.
Journal ArticleDOI
Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression.
David A. Alagpulinsa,Jenny J L Cao,Jenny J L Cao,Riley K Driscoll,Riley K Driscoll,Ruxandra F. Sîrbulescu,Madeline F.E. Penson,Marinko Sremac,Elise N. Engquist,Timothy Brauns,James F. Markmann,Douglas A. Melton,Mark C. Poznansky +12 more
TL;DR: A novel approach to evade the pericapsular fibrotic response to alginate‐microencapsulated SC‐β cells was used, resulting in long‐term functional competence and glycemic correction without systemic immunosuppression in immunocompetent C57BL/6 mice.
Journal ArticleDOI
Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes
Barbara Ludwig,Stefan Ludwig,Anja Steffen,Yvonne Knauf,Baruch Zimerman,Sophie Heinke,Susann Lehmann,Undine Schubert,Janine Schmid,Martina Bleyer,Uwe Schönmann,Clark K. Colton,Ezio Bonifacio,Michele Solimena,Michele Solimena,Andreas Reichel,Andrew V. Schally,Avi Rotem,Uriel Barkai,Helena Grinberg-Rashi,F. J. Kaup,Yuval Avni,Peter M. Jones,Stefan R. Bornstein +23 more
TL;DR: Successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions.
References
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Journal ArticleDOI
Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen
A. M. J. Shapiro,Jonathan R. T. Lakey,Edmond A. Ryan,Gregory S. Korbutt,Ellen L. Toth,Garth L. Warnock,Norman M. Kneteman,Ray V. Rajotte +7 more
TL;DR: The observations in patients with type 1 diabetes indicate that islet transplantation can result in insulin independence with excellent metabolic control when glucocorticoid-free immunosuppression is combined with the infusion of an adequate islet mass.
Book
Introduction to protein structure
Carl Ivar Branden,John Tooze +1 more
TL;DR: Part 1 BASIC STRUCTURAL PRINCIPLES: The Building Blocks and Motifs of Protein Structure and Part 2 STRUCTURE, FUNCTION and ENGINEERING: Structure, Function and Engineering.
Journal ArticleDOI
Mesenchymal stem cells in health and disease
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Journal ArticleDOI
Macrophage activation and polarization.
TL;DR: The main functions of polarized macrophages are reviewed and the perspectives of this field are discussed, which include high endocytic clearance capacities and trophic factor synthesis, accompanied by reduced pro-inflammatory cytokine secretion.
Journal ArticleDOI
Microencapsulated islets as bioartificial endocrine pancreas
Franklin Lim,Anthony M. Sun +1 more
TL;DR: The microencapsulated islets remained morphologically and functionally intact throughout long-term culture studies lasting over 15 weeks.
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