Journal ArticleDOI
Advances in islet encapsulation technologies
Tejal A. Desai,Lonnie D. Shea +1 more
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TLDR
Although encapsulation technology has met several challenges, the convergence of expertise in materials, nanotechnology, stem cell biology and immunology is allowing the goal of encapsulated islet cell therapy for humans to be closer.Abstract:
Type 1 diabetes is an autoimmune disorder in which the immune system attacks and destroys insulin-producing islet cells of the pancreas. Although islet transplantation has proved to be successful for some patients with type 1 diabetes, its widespread use is limited by islet donor shortage and the requirement for lifelong immunosuppression. An encapsulation strategy that can prevent the rejection of xenogeneic islets or of stem cell-derived allogeneic islets can potentially eliminate both of these barriers. Although encapsulation technology has met several challenges, the convergence of expertise in materials, nanotechnology, stem cell biology and immunology is allowing us to get closer to the goal of encapsulated islet cell therapy for humans.read more
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3D printing of hydrogels: Rational design strategies and emerging biomedical applications
TL;DR: A review of hydrogel-based biomaterial inks and bioinks for 3D printing can be found in this paper, where the authors provide a comprehensive overview and discussion of the tailorability of material, mechanical, physical, chemical and biological properties.
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Non-invasive delivery strategies for biologics.
TL;DR: This Review summarizes the current status, latest updates and future prospects for delivery of peptides, proteins and other biologics, including subcutaneous, transdermal, oral, inhalation, nasal and buccal routes.
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Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery
TL;DR: The article presents the most important structures of microparticles (microspheres, microcapsules, coated pellets, etc.), interpreted with microscopic images too, as well as the drug release mechanisms and commonly used excipients.
Journal ArticleDOI
Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques.
Matthew A. Bochenek,Omid Veiseh,Arturo J. Vegas,James J. McGarrigle,Meirigeng Qi,Enza Marchese,Mustafa Omami,Joshua C. Doloff,Joshua C. Doloff,Joshua E. Mendoza-Elias,Mohammad Nourmohammadzadeh,Mohammad Nourmohammadzadeh,Arshad Khan,Chun Chieh Yeh,Yuan Xing,Yuan Xing,Douglas Isa,Sofia Ghani,Jie Li,Casey E. Landry,Casey E. Landry,Andrew Bader,Andrew Bader,Karsten Olejnik,Michael Chen,Michael Chen,Jennifer Hollister-Lock,Yong Wang,Yong Wang,Dale L. Greiner,Gordon C. Weir,Berit L. Strand,Anne Mari Rokstad,Igor Lacík,Robert Langer,Daniel G. Anderson,Jose Oberholzer,Jose Oberholzer +37 more
TL;DR: Transplantation of pancreatic islet cells encapsulated in alginate microspheres into the omental bursa of the peritoneal cavity of NHPs significantly reduces FBRs and extends the longevity of the cells.
Journal ArticleDOI
Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges
Julie B. Sneddon,Qizhi Tang,Peter G. Stock,Jeffrey A. Bluestone,Shuvo Roy,Tejal A. Desai,Matthias Hebrok +6 more
TL;DR: Current efforts aimed at generating a sustainable source of functional human stem cell-derived insulin-producing islet cells for cell transplantation are described and state-of-the-art efforts to protect such cells via immune modulation and encapsulation strategies are presented.
References
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Journal ArticleDOI
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