Journal ArticleDOI
Alginate based 3D hydrogels as an in vitro co-culture model platform for the toxicity screening of new chemical entities.
Shih-Feng Lan,Binil Starly +1 more
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TLDR
An in vitro 3D co-culture platform provides a scalable and flexible approach to test multiple-cell types in a hybrid setting within standard cell culture plates which may open up novel 3D in vitro culture techniques to screen new chemical entity compounds.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 2011-10-01. It has received 85 citations till now. The article focuses on the topics: In vivo & Alternatives to animal testing.read more
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Recent advances in hydrogel based drug delivery systems for the human body
TL;DR: The role of hydrogels as delivery vehicles for drugs used in various disorders related to the brain and other distinct parts of the human body and their potential for diagnostics and various therapeutic interventions against tuberculosis are summarized.
Journal ArticleDOI
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing.
David A. Basketter,Harvey J. Clewell,Ian Kimber,Annamaria Rossi,Bas J. Blaauboer,Robert Burrier,Mardas Daneshian,Chantra Eskes,Alan M. Goldberg,Nina Hasiwa,Sebastian Hoffmann,Joanna Jaworska,Thomas B. Knudsen,Robert Landsiedel,Marcel Leist,Paul A. Locke,Gavin Maxwell,James M. McKim,Emily A. McVey,Gladys Ouedraogo,Grace Patlewicz,Olavi Pelkonen,Erwin Ludo Roggen,Costanza Rovida,Irmela Ruhdel,Michael Schwarz,Andreas Schepky,Greet Schoeters,Nigel Skinner,Kerstin Trentz,Marian Turner,Philippe Vanparys,James D. Yager,Joanne Zurlo,Thomas Hartung +34 more
TL;DR: In this paper, the authors present a roadmap for how to overcome the acknowledged scientific gaps for the full replacement of systemic toxicity testing using animals, which is a major concern for the current state of the art.
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Recent Advances in Edible Polymer Based Hydrogels as a Sustainable Alternative to Conventional Polymers.
Akbar Ali,Shakeel Ahmed +1 more
TL;DR: The application of edible polymer hydrogels covers many areas including the food industry, agricultural applications, drug delivery to tissue engineering in the biomedical field and provide more safe and attractive products in the pharmaceutical, agricultural, and environmental fields, etc.
Journal ArticleDOI
Modeling human carcinomas: physiologically relevant 3D models to improve anti-cancer drug development.
Christine Unger,Nina Kramer,Angelika Walzl,Martin Scherzer,Markus Hengstschläger,Helmut Dolznig +5 more
TL;DR: An overview of available in vivo and in vitro models of cancer, which meet the criteria of being 3D and mirroring human tumor-stroma interactions, and only focuses on drug response models without touching models for pharmacokinetic and dynamic, toxicity or delivery aspects.
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Bioengineered 3D human kidney tissue, a platform for the determination of nephrotoxicity.
TL;DR: A 3D kidney tissue model using immortalized human renal cortical epithelial cells with kidney functions similar to that found in vivo is bioengineered to allow for better prediction of the nephrotoxic effects of new drugs.
References
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DrugBank: a knowledgebase for drugs, drug actions and drug targets
David S. Wishart,Craig Knox,An Chi Guo,Dean Cheng,Savita Shrivastava,Dan Tzur,Bijaya Gautam,Murtaza Hassanali +7 more
TL;DR: The latest version of DrugBank (release 2.0) has been expanded significantly over the previous release and contains 60% more FDA-approved small molecule and biotech drugs including 10% more ‘experimental’ drugs.
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Modeling Tissue Morphogenesis and Cancer in 3D
Kenneth M. Yamada,Edna Cukierman +1 more
TL;DR: Three-dimensional (3D) in vitro models provide unique perspectives on the behavior of stem cells, developing tissues and organs, and tumors and may help to accelerate translational research in cancer biology and tissue engineering.
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Microscale culture of human liver cells for drug development
TL;DR: This work presents a miniaturized, multiwell culture system for human liver cells with optimized microscale architecture that maintains phenotypic functions for several weeks and demonstrates utility through assessment of gene expression profiles, phase I/II metabolism, canalicular transport, secretion of liver-specific products and susceptibility to hepatotoxins.
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N-acetyl-p- benzoquinone imine a cytochrome P-450 mediated oxidation product of acetaminophen
TL;DR: Results of partitioning experiments indicate that N-acetyl-p-benzoquinone imine is a major metabolite of acetaminophen, a considerable fraction of which is rapidly reduced back toacetaminophen.
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High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array
Yi-Chung Tung,Yi-Chung Tung,Amy Y. Hsiao,Steven G. Allen,Yu Suke Torisawa,Mitchell Ho,Shuichi Takayama,Shuichi Takayama +7 more
TL;DR: A 384-well format hanging drop culture plate is described that makes spheroid formation, culture, and subsequent drug testing on the obtained 3D cellular constructs as straightforward to perform and adapt to existing high-throughput screening (HTS) instruments as conventional 2D cultures.