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Open AccessJournal ArticleDOI

Alginate: properties and biomedical applications

Kuen Yong Lee, +1 more
- 01 Jan 2012 - 
- Vol. 37, Iss: 1, pp 106-126
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TLDR
This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.
About
This article is published in Progress in Polymer Science.The article was published on 2012-01-01 and is currently open access. It has received 5372 citations till now. The article focuses on the topics: Self-healing hydrogels.

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Citations
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Designing hydrogels for controlled drug delivery.

TL;DR: This Review discusses how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation, and collects experimental release data from the literature and presents quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
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Alginate derivatization: a review of chemistry, properties and applications.

TL;DR: Progress towards controlled synthesis of alginate derivatives, and the properties and applications of these derivatives are reviewed.
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3D Bioprinting Human Chondrocytes with Nanocellulose-Alginate Bioink for Cartilage Tissue Engineering Applications

TL;DR: A bioink that combines the outstanding shear thinning properties of nanofibrillated cellulose (NFC) with the fast cross-linking ability of alginate with the potential use of nanocellulose for 3D bioprinting of living tissues and organs is formulated.
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A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings

TL;DR: In this article, the authors present the past and current efforts with a brief description on the featured properties of hydrogel membranes fabricated from biopolymers and synthetic ones for wound dressing applications.
References
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Journal ArticleDOI

Shape-defining scaffolds for minimally invasive tissue engineering.

TL;DR: Shaped hydrogels, formed by covalently cross-linking, can be structurally collapsed into smaller, temporary shapes that permit their minimally invasive delivery in vivo and permits neotissue formation in desired geometries.
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Vascular endothelial growth factor-releasing scaffolds enhance vascularization and engraftment of hepatocytes transplanted on liver lobes.

TL;DR: Sustained local delivery of VEGF induced vascularization of porous scaffolds implanted on liver lobes and improved hepatocyte engraftment is shown.
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Patterning alginate hydrogels using light-directed release of caged calcium in a microfluidic device

TL;DR: This paper describes a simple reversible hydrogel patterning method for 3D cell culture and demonstrates application of this capability to patterned microscale 3D co-culture using endothelial cells and osteoblastic cells in a microchannel.
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Reconstruction of rat peripheral nerve gap without sutures using freeze-dried alginate gel.

TL;DR: Freeze-dried alginate gel is a promising material for artificial nerve guides for peripheral nerves and also could be used for repair of disrupted pathways in central nervous tissue that is amorphous and cannot be sutured.
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