Alginate: properties and biomedical applications
Kuen Yong Lee,David J. Mooney +1 more
TLDR
This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.About:
This article is published in Progress in Polymer Science.The article was published on 2012-01-01 and is currently open access. It has received 5372 citations till now. The article focuses on the topics: Self-healing hydrogels.read more
Citations
More filters
Journal ArticleDOI
Gene Delivery of TGF-β3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering.
Tomas Gonzalez-Fernandez,Erica G. Tierney,Gráinne M. Cunniffe,Gráinne M. Cunniffe,Fergal J. O'Brien,Fergal J. O'Brien,Daniel J. Kelly +6 more
TL;DR: Results suggest that the developed gene-activated alginate hydrogels were able to support transfection of encapsulated MSCs and directed their phenotype toward either a chondrogenic or an osteogenic phenotype depending on whether TGF-β3 and BMP2 were delivered in combination or isolation.
Journal ArticleDOI
Synthetic hydrogels mimicking basement membrane matrices to promote cell-matrix interactions
TL;DR: This review provides an overview of successful approaches to convey basement membrane-like bioactivity into 3D artificial hydrogel matrices in order to recapitulate cellular responses to native matrices and highlights how the tunable physicochemical properties of biofunctionalized synthetic hydroges can be exploited to study the separate contributions of biochemical and biophysical matrix properties to different cellular processes.
Journal ArticleDOI
Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27Kip1 signaling axis
Sungmin Nam,Vivek K. Gupta,Hong-pyo Lee,Joanna Y. Lee,Katrina M. Wisdom,Sushama Varma,Eliott Flaum,Ciara Davis,Robert B. West,Ovijit Chaudhuri +9 more
TL;DR: In confining microenvironments, cells sense when growth is sufficient for division to proceed through a growth-responsive signaling axis mediated by SACs, and are arrested in the G0/G1 phase of the cell cycle when cultured in hydrogels that exhibit slow stress relaxation.
Journal ArticleDOI
Becoming Sustainable, The New Frontier in Soft Robotics.
TL;DR: This review outlines the rise of sustainable materials in soft and bioinspired robotics, targeting all robotic components from actuators to energy storage and electronics, and outlines the first steps initiate the evolution of robotics and guide them into a sustainable future.
Journal ArticleDOI
Mucoadhesive alginate pastes with embedded liposomes for local oral drug delivery
Yarden Shtenberg,Mor Goldfeder,Hodaya Prinz,Janna Shainsky,Yasmine Ghantous,Imad Abu El-Naaj,Avi Schroeder,Havazelet Bianco-Peled +7 more
TL;DR: The innovative formulation, including both desired characteristics of mucoadhesion and sustained liposomes release, is an important milestone in the development of a new potential treatment for oral cancer.
References
More filters
Journal ArticleDOI
Chitin and chitosan: Properties and applications
TL;DR: Chitin is the second most important natural polymer in the world as mentioned in this paper, and the main sources of chitin are two marine crustaceans, shrimp and crabs, which are used for food, cosmetics, biomedical and pharmaceutical applications.
Journal ArticleDOI
Angiogenesis in life, disease and medicine
TL;DR: Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments.
Journal ArticleDOI
Biological interactions between polysaccharides and divalent cations: The egg‐box model
TL;DR: It is shown that spedfic binding of divalent cations to a polysaechafide polyelectro]ym, leading firm cohesion between the chains, can cause characteristic effects in the c~rcutar diehroism spectrum which are understandabb in terms of modem theo~, [ l ].
Related Papers (5)
Alginate hydrogels as synthetic extracellular matrix materials
Hydrogels for tissue engineering: scaffold design variables and applications.
Jeanie L. Drury,David J. Mooney +1 more
Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review.
Meera George,T. Emilia Abraham +1 more