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Open AccessJournal ArticleDOI

Alginate: properties and biomedical applications

Kuen Yong Lee, +1 more
- 01 Jan 2012 - 
- Vol. 37, Iss: 1, pp 106-126
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TLDR
This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.
About
This article is published in Progress in Polymer Science.The article was published on 2012-01-01 and is currently open access. It has received 5372 citations till now. The article focuses on the topics: Self-healing hydrogels.

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Citations
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Designing hydrogels for controlled drug delivery.

TL;DR: This Review discusses how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation, and collects experimental release data from the literature and presents quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
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Alginate derivatization: a review of chemistry, properties and applications.

TL;DR: Progress towards controlled synthesis of alginate derivatives, and the properties and applications of these derivatives are reviewed.
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3D Bioprinting Human Chondrocytes with Nanocellulose-Alginate Bioink for Cartilage Tissue Engineering Applications

TL;DR: A bioink that combines the outstanding shear thinning properties of nanofibrillated cellulose (NFC) with the fast cross-linking ability of alginate with the potential use of nanocellulose for 3D bioprinting of living tissues and organs is formulated.
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A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings

TL;DR: In this article, the authors present the past and current efforts with a brief description on the featured properties of hydrogel membranes fabricated from biopolymers and synthetic ones for wound dressing applications.
References
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Journal ArticleDOI

A cellular implantation system using an injectable ultra-purified alginate gel for repair of osteochondral defects in a rabbit model.

TL;DR: A novel cellular implantation system using an in situ forming ultra-purified alginate gel with quite low endotoxity shows the clinical potential for arthroscopically injectable implantation of BMSCs for the treatment of cartilaginous lesions.
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Effect of alginate composition and purity on alginate microspheres.

TL;DR: High purified high-mannuronic acid alginate will provide smaller, spherical microcapsules suitable for islet cell transplantation, and less polymorphism was found with the HPLVM microspheres than with the ILVM microbeads.
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Zinc in wound repair.

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Chondrocyte calcium signaling in response to fluid flow is regulated by matrix adhesion in 3-D alginate scaffolds

TL;DR: A role for matrix adhesion in regulating chondrocyte response to fluid flow through a calcium dependent mechanism is indicated.
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Viability and functionality of cells delivered from peptide conjugated scaffolds.

TL;DR: Alginate-OEC interactions do not adversely affect these cells, validating control of cellular migration as a means to control the cell delivery profile from the material system, and supporting usage of the alginate scaffold as an efficient cell delivery vehicle are suggested.
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