Alveolar Macrophages Are the Primary Interferon-α Producer in Pulmonary Infection with RNA Viruses
Yutaro Kumagai,Osamu Takeuchi,Hiroki Kato,Himanshu Kumar,Kosuke Matsui,Eiichi Morii,Katsuyuki Aozasa,Taro Kawai,Shizuo Akira +8 more
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TLDR
A knockin mouse in which green fluorescence protein (GFP) was expressed under the control of the Ifna6 promoter generated a type I IFN producer that is important for the initial responses to viral infection in the lung.About:
This article is published in Immunity.The article was published on 2007-08-24 and is currently open access. It has received 363 citations till now. The article focuses on the topics: Virus & Green fluorescent protein.read more
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Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity
Taro Kawai,Shizuo Akira +1 more
TL;DR: The role played by TLRs in mounting protective immune responses against infection and their crosstalk with other PRRs with respect to pathogen recognition is focused on.
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The roles of TLRs, RLRs and NLRs in pathogen recognition
Taro Kawai,Shizuo Akira +1 more
TL;DR: Recent insights into pathogen sensing by PRRs are summarized and specific signaling pathways that lead to expression of genes that tailor immune responses to particular microbes are summarized.
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Innate immunity to virus infection.
Osamu Takeuchi,Shizuo Akira +1 more
TL;DR: This review discusses recent advances in the understanding of the mechanisms of viral RNA recognition by these different types of receptors and its relation to acquired immune responses.
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The multifaceted biology of plasmacytoid dendritic cells
Melissa Swiecki,Marco Colonna +1 more
TL;DR: Recent progress in the field of pDC biology is summarized, focusing on the molecular mechanisms that regulate the development and functions of p DCs, the pathways involved in their sensing of pathogens and endogenous nucleic acids, their functions at mucosal sites, and their roles in infection, autoimmunity and cancer.
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Macrophages: development and tissue specialization
TL;DR: Two major recent paradigm shifts in the understanding of tissue macrophage biology are reviewed, including the realization that most tissue-resident macrophages are established prenatally and maintained through adulthood by longevity and self-renewal and the recognition of tissue specialization in response to local environmental cues.
References
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Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Mitsutoshi Yoneyama,Mika Kikuchi,Takashi Natsukawa,Noriaki Shinobu,Tadaatsu Imaizumi,Makoto Miyagishi,Kazunari Taira,Shizuo Akira,Takashi Fujita +8 more
TL;DR: In this article, the authors identify retinoic acid inducible gene I (RIG-I), which encodes a DExD/H box RNA helicase that contains a caspase recruitment domain, as an essential regulator for dsRNA-induced signaling.
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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Hiroki Kato,Osamu Takeuchi,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Kosuke Matsui,Satoshi Uematsu,Andreas Jung,Taro Kawai,Ken Ishii,Osamu Yamaguchi,Kinya Otsu,Tohru Tsujimura,Chang-Sung Koh,Caetano Reis e Sousa,Yoshiharu Matsuura,Takashi Fujita,Shizuo Akira +17 more
TL;DR: It is found that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection.
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Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
TL;DR: The identification of a novel protein termed MAVS (mitochondrial antiviral signaling), which mediates the activation of NF-kappaB and IRF 3 in response to viral infection, and implicates a new role of mitochondria in innate immunity.
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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Hiroaki Hemmi,Tsuneyasu Kaisho,Osamu Takeuchi,Shintaro Sato,Hideki Sanjo,Katsuaki Hoshino,Takao Horiuchi,Hideyuki Tomizawa,Kiyoshi Takeda,Shizuo Akira +9 more
TL;DR: It is shown that the imidazoquinolines activate immune cells via the Toll-like receptor 7 (TLR7)-MyD88–dependent signaling pathway, and that neither MyD88- nor TLR7-deficient mice showed any inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of dendritic cells.