Journal ArticleDOI
Anti-tyrosinase, anti-cholinesterase and cytotoxic activities of extracts and phytochemicals from the Tunisian Citharexylum spinosum L.: Molecular docking and SAR analysis.
Ilyes Saidi,Vijaykumar D. Nimbarte,Harald Schwalbe,Pierre Waffo-Teguo,Abdel Halim Harrath,Lamjed Mansour,Saleh Alwasel,Hichem Ben Jannet +7 more
TLDR
Biological evaluation of the structure-activity relationship of Citharexylum spinosum L. tree showed that the EtOAc extract of the trunk bark displayed the highest anti-tyrosinase effect and the highest anticholinesterase activity, while the natural compounds that exhibited the significant bioactivities were docked.About:
This article is published in Bioorganic Chemistry.The article was published on 2020-07-14. It has received 12 citations till now. The article focuses on the topics: Iridoid Glycosides & Citharexylum spinosum.read more
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Metabolomic insight into the profile, in vitro bioaccessibility and bioactive properties of polyphenols and glucosinolates from four Brassicaceae microgreens.
TL;DR: In this paper, four Brassicaceae microgreens species, namely kale, red cabbage, kohlrabi, and radish, were evaluated for their phytochemical compositions using spectrophotometric assays and untargeted metabolomics before and after in vitro gastrointestinal digestion.
Journal ArticleDOI
Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources.
Alfred Ngenge Tamfu,Selcuk Kucukaydin,Balakyz Yeskaliyeva,Mehmet Öztürk,Rodica Mihaela Dinica +4 more
TL;DR: In this paper, a review summarizes information about the therapeutic potential of small natural molecules from medicinal herbs, belonging to terpenoids, coumarins, and phenolic compounds, which have gained special attention due to their specific modes of action and their advantages of low toxicity and high efficiency in the treatment of Alzheimer's disease.
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Chemical Characterization, Antioxidant, Enzyme Inhibition and Antimutagenic Properties of Eight Mushroom Species: A Comparative Study.
TL;DR: Results presented in this study tend to show that the mushroom species could be exploited as potential sources of therapeutic bioactive agents, geared towards the management of oxidative stress, global health problems and cancer.
Journal ArticleDOI
Synthesis of new halogenated flavonoid-based isoxazoles: in vitro and in silico evaluation of a-amylase inhibitory potential, a SAR analysis and DFT studies
TL;DR: In this paper, the authors describe the design, the synthesis and the α-amylase inhibitory potential of new halogenated flavonoid-based isoxazoles, and their biological properties.
Journal ArticleDOI
Synthesis of new halogenated flavonoid-based isoxazoles: in vitro and in silico evaluation of a-amylase inhibitory potential, a SAR analysis and DFT studies
TL;DR: In this paper , the authors describe the design, the synthesis and the α-amylase inhibitory potential of new halogenated flavonoid-based isoxazoles, and their biological properties.
References
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To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
TL;DR: Delivery of conventional chemotherapeutic anti-cancer drugs is mainly discussed and exploitation and the understanding of these characteristics to design new drug delivery systems targeting the tumor are focused on.
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Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective.
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Acetylcholinesterase inhibitors from plants
TL;DR: This article aims to provide a comprehensive literature survey of plants that have been tested for AChE inhibitory activity and reports numerous phytoconstituents and promising plant species as A ChE inhibitors.
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Crystal structure of Agaricus bisporus mushroom tyrosinase: identity of the tetramer subunits and interaction with tropolone.
Wangsa T. Ismaya,Henriëtte J. Rozeboom,A. Weijn,Jurriaan J. Mes,Fabrizia Fusetti,Harry J. Wichers,Bauke W. Dijkstra +6 more
TL;DR: The first structure of the full fungal tyrosinase complex from the mushroom Agaricus bisporus is presented, explaining how calcium ions stabilize the tetrameric state of the enzyme.
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Recent advances in research on lignans and neolignans
TL;DR: This review describes 564 of the latest examples of naturally occurring lignans and neolignans, and their glycosides in some cases, which have been isolated between 2009 and 2015 and highlights the biosynthesis and total synthesis of some important ones.