Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects.
Tanvir Mahtab Uddin,Arka Jyoti Chakraborty,Ameer Khusro,Bm Redwan Matin Zidan,Saikat Mitra,Talha Bin Emran,Kuldeep Dhama,Kamal Hossain Ripon,Márió Gajdács,Muhammad Umar Khayam Sahibzada,Jamal Hossain,Niranjan Koirala +11 more
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TLDR
Antibiotics have been used to cure bacterial infections for more than 70 years, and these low-molecular-weight bioactive agents have also been used for a variety of other medicinal applications.About:
This article is published in Journal of Infection and Public Health.The article was published on 2021-10-23 and is currently open access. It has received 99 citations till now. The article focuses on the topics: Antibiotic resistance & Antibiotics.read more
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Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace
David Chinemerem Nwobodo,Malachy C Ugwu,Clement Oliseloke Anie,Mushtak T.S. Al-Ouqaili,Joseph Chinedu Ikem,Uchenna Victor Chigozie,Morteza Saki +6 more
TL;DR: This review summarized some new strategies for tackling antibiotic resistance in bacteria, and highlighted the need for new antibiotics and other antimicrobials to be developed in the coming years.
Journal ArticleDOI
Evaluation of the Antimicrobial and Antivirulent Potential of Essential Oils Isolated from Juniperus oxycedrus L. ssp. macrocarpa Aerial Parts
Gabriella Spengler,Márió Gajdács,Matthew Gavino Donadu,Marianna Usai,Mario Marchetti,Marco Ferrari,Vittorio Mazzarello,Stefania Anna Lucia Zanetti,Fruzsina Nagy,Renátó Kovács +9 more
TL;DR: The essential oil from the Sardinian endemic Juniperus oxycedrus may be promising for future more extensive research and in vivo tests to develop new drugs against antibiotic and antifungal resistance.
Journal ArticleDOI
Co-Infections, Secondary Infections, and Antimicrobial Use in Patients Hospitalized with COVID-19 during the First Five Waves of the Pandemic in Pakistan; Findings and Implications
Kiran Ramzan,Sameen Shafiq,Iqra Raees,Zia Ul Mustafa,Muhammad Salman,Amer Hayat Khan,Johanna C Meyer,Brian Godman +7 more
TL;DR: Excessive prescribing of antibiotics is still occurring among COVID-19 patients in Pakistan; however, rates are reducing, and urgent measures are needed for further reductions.
Journal ArticleDOI
Extracellular polymeric substances—antibiotics interaction in activated sludge: A review
Weixin Zhao,Jia You,Shi-zhong Yin,Hai Rui Yang,Shufei He,Likui Feng,Jianju Li,Qing Xiao Zhao,Liangliang Wei +8 more
TL;DR: In this paper , the authors summarized the composition and physicochemical characteristics of state-of-the-art microbial EPS, highlighted the critical role of EPS in antibiotics removal, evaluated their defense performances under different antibiotics exposures, and analyzed the typical factors that could affect the sorption and biotransformation behavior of antibiotics.
Journal ArticleDOI
Deep learning research should be encouraged for diagnosis and treatment of antibiotic resistance of microbial infections in treatment associated emergencies in hospitals.
Chiranjib Chakraborty,Manojit Bhattacharya,Ashish Ranjan Sharma,Sanjiban Sekhar Roy,Md Aminul Islam,Subrata Chakraborty,Shyam Sundar Nandi,Kuldeep Dhama +7 more
References
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CRISPR provides acquired resistance against viruses in prokaryotes
Rodolphe Barrangou,Christophe Fremaux,Hélène Deveau,Melissa Richards,Patrick Boyaval,Sylvain Moineau,Dennis A. Romero,Philippe Horvath +7 more
TL;DR: It is found that, after viral challenge, bacteria integrated new spacers derived from phage genomic sequences, and CRISPR provided resistance against phages, and resistance specificity is determined by spacer-phage sequence similarity.
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Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation
Nuala A. O'Leary,Mathew W. Wright,J. Rodney Brister,Stacy Ciufo,Diana Haddad,Richard McVeigh,Bhanu Rajput,Barbara Robbertse,Brian Smith-White,Danso Ako-adjei,Alexander Astashyn,Azat Badretdin,Yiming Bao,Olga Blinkova,Vyacheslav Brover,Vyacheslav Chetvernin,Jinna Choi,Eric Cox,Olga Ermolaeva,Catherine M. Farrell,Tamara Goldfarb,Tripti Gupta,Daniel H. Haft,Eneida L. Hatcher,Wratko Hlavina,Vinita Joardar,Vamsi K. Kodali,Wenjun Li,Donna Maglott,Patrick Masterson,Kelly M. McGarvey,Michael R. Murphy,Kathleen O'Neill,Shashikant Pujar,Sanjida H. Rangwala,Daniel Rausch,Lillian D. Riddick,Conrad L. Schoch,Andrei Shkeda,Susan S. Storz,Hanzhen Sun,Françoise Thibaud-Nissen,Igor Tolstoy,Raymond E. Tully,Anjana R. Vatsan,Craig Wallin,David Webb,Wendy Wu,Melissa J. Landrum,Avi Kimchi,Tatiana Tatusova,Michael DiCuccio,Paul Kitts,Terence Murphy,Kim D. Pruitt +54 more
TL;DR: The approach to utilizing available RNA-Seq and other data types in the authors' manual curation process for vertebrate, plant, and other species is summarized, and a new direction for prokaryotic genomes and protein name management is described.
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Molecular mechanisms of antibiotic resistance.
TL;DR: Recent advances in understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics are reviewed, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.
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In Silico Detection and Typing of Plasmids using PlasmidFinder and Plasmid Multilocus Sequence Typing
Alessandra Carattoli,Ea Zankari,Aurora García-Fernández,Mette Voldby Larsen,Ole Lund,Laura Villa,Frank Møller Aarestrup,Henrik Hasman +7 more
TL;DR: Two easy-to-use Web tools for in silico detection and characterization of whole-genome sequence (WGS) and whole-plasmid sequence data from members of the family Enterobacteriaceae are designed and developed.
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Small CRISPR RNAs guide antiviral defense in prokaryotes
Stan J. J. Brouns,Matthijs M. Jore,Magnus Lundgren,Edze R. Westra,Rik J. H. Slijkhuis,Ambrosius P. Snijders,Mark J. Dickman,Kira S. Makarova,Eugene V. Koonin,John van der Oost +9 more
TL;DR: The results demonstrate that the formation of mature guide RNAs by the CRISPR RNA endonuclease subunit of Cascade is a mechanistic requirement for antiviral defense.
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