Journal ArticleDOI
Beclin 1: a BH3-only protein that fails to induce apoptosis
TLDR
The intriguing finding that Bcl-2, as it interacts with Beclin 1, does not lose its anti-apoptotic potential may have far-reaching implications for the comprehension of the cross-talk between apoptosis and autophagy.Abstract:
Beclin 1 has been recently shown to possess a Bcl-2 homology-3 (BH3) domain that mediates its interaction with antiapoptotic multidomain proteins Unlike other BH3-only proteins, Beclin 1 fails to stimulate apoptosis when it is overexpressed In this issue of Oncogene, Ciechomska et al report the intriguing finding that Bcl-2, as it interacts with Beclin 1, does not lose its anti-apoptotic potential This finding may have far-reaching implications for the comprehension of the cross-talk between apoptosis and autophagyread more
Citations
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Journal ArticleDOI
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
Ellen Wirawan,L Vande Walle,Kristof Kersse,Sigrid Cornelis,Sigrid Cornelis,Sofie Claerhout,Isabel Vanoverberghe,Ria Roelandt,R. De Rycke,Jelle Verspurten,Wim Declercq,Patrizia Agostinis,T Vanden Berghe,Saskia Lippens,Peter Vandenabeele +14 more
TL;DR: Findings point to a mechanism by which casp-dependent generation of Beclin-1-C creates an amplifying loop enhancing apoptosis upon growth factor withdrawal.
Journal ArticleDOI
Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis
Feifan Zhou,Ying Yang,Da Xing +2 more
TL;DR: Bcl‐2 and Bcl‐xL, the well‐characterized apoptosis guards, appear to be important factors in autophagy, inhibiting Beclin 1‐mediated autophagic activity by binding to Becl in addition to cooperating with Atg5 or Ca2+ to regulate bothAutophagy and apoptosis.
Journal ArticleDOI
Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1
TL;DR: The significant finding that caspases can cleave Beclin 1, thereby destroying its pro-autophagic activity is reported, which provides important insights into the molecular cross talk between autophagy and apoptosis.
Journal ArticleDOI
The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis
TL;DR: The essential autophagy protein Atg 12 is identified as a positive mediator of mitochondrial apoptosis and it is shown that Atg12 directly regulates the apoptotic pathway by binding and inactivating prosurvival B cl-2 family members, including Bcl-2 and Mcl-1.
Journal ArticleDOI
Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress
TL;DR: Current knowledge regarding how ER stress and the unfolded protein response (UPR) induce autophagy is reviewed, including description of the different autophagic-related genes which are regulated by the UPR.
References
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Journal ArticleDOI
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.
Sophie Pattingre,Sophie Pattingre,Amina T. Tassa,Xueping Qu,Xueping Qu,Rita Garuti,Xiao Huan Liang,Noboru Mizushima,Milton Packer,Michael D. Schneider,Beth Levine,Beth Levine +11 more
TL;DR: Bcl-2 not only functions as an antiapoptotic protein, but also as an antiautophagy protein via its inhibitory interaction with Beclin 1, which may help maintain autophagy at levels that are compatible with cell survival, rather than cell death.
Journal ArticleDOI
Induction of autophagy and inhibition of tumorigenesis by beclin 1.
Xiao Huan Liang,Saadiya Jackson,Matthew N.J. Seaman,Kristy A. Brown,Bettina Kempkes,Hanina Hibshoosh,Beth Levine +6 more
TL;DR: It is shown that beclin 1 is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at decreased levels in human breast carcinoma, suggesting that decreased expression of Autophagy proteins may contribute to the development or progression of breast and other human malignancies.
Journal ArticleDOI
The Bcl-2 apoptotic switch in cancer development and therapy
J. M. Adams,Suzanne Cory +1 more
TL;DR: Better understanding of the Bcl-2 family is clarifying its role in cancer development, revealing how conventional therapy works and stimulating the search for ‘BH3 mimetics’ as a novel class of anticancer drugs.
Journal ArticleDOI
Autophagic cell death: the story of a misnomer
Guido Kroemer,Beth Levine +1 more
TL;DR: This work evaluates the accumulating body of literature that argues that cell death occurs by autophagy and lists the caveats that must be considered when deciding whether or notAutophagy is an important effector mechanism of cell death.
Journal ArticleDOI
JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy
Yongjie Wei,Sophie Pattingre,Sangita C. Sinha,Michael C. Bassik,Michael C. Bassik,Beth Levine +5 more
TL;DR: It is demonstrated that JNK1-mediated multisite phosphorylation of Bcl-2 stimulates starvation-induced autophagy by disrupting the B cl-2/Beclin 1 complex, which defines a mechanism that cells use to regulate autophagic activity in response to nutrient status.
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Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1
M. Chiara Maiuri,Gaetane Le Toumelin,Alfredo Criollo,Alfredo Criollo,Alfredo Criollo,Jean-Christophe Rain,Fabien Gautier,Philippe Juin,Ezgi Tasdemir,Ezgi Tasdemir,Ezgi Tasdemir,Gérard Pierron,Kostoula Troulinaki,Nektarios Tavernarakis,John A. Hickman,Olivier Geneste,Guido Kroemer,Guido Kroemer,Guido Kroemer +18 more