Journal ArticleDOI
Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
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TLDR
This review focuses on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.Abstract:
Chemokines are chemotactic cytokines that control the migratory patterns and positioning of all immune cells. Although chemokines were initially appreciated as important mediators of acute inflammation, we now know that this complex system of approximately 50 endogenous chemokine ligands and 20 G protein–coupled seven-transmembrane signaling receptors is also critical for the generation of primary and secondary adaptive cellular and humoral immune responses. Recent studies demonstrate important roles for the chemokine system in the priming of naive T cells, in cell fate decisions such as effector and memory cell differentiation, and in regulatory T cell function. In this review, we focus on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.read more
Citations
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Journal ArticleDOI
Platelet CD40 Mediates Leukocyte Recruitment and Neointima Formation after Arterial Denudation Injury in Atherosclerosis-Prone Mice.
TL;DR: It is shown that neointima formation after carotid artery wire injury reduces markedly in CD40-/- apolipoprotein E-deficient mice but only slightly inCD40 ligand-/-apoE-/- mice, and platelet CD40 might represent an attractive target to prevent restenosis after vascular interventions.
Journal ArticleDOI
Analysis of therapeutic targets and prognostic biomarkers of CXC chemokines in cervical cancer microenvironment
Wei na Kong,Gang Zhao,Hai xia Chen,Wei na Wang,Xiao qian Shang,Qian nan Sun,Fan Guo,Xiumin Ma +7 more
TL;DR: The data suggest that RELA, NFKB1, and SP1 are key transcription factors for CXC chemokines, and the LCK, LYN and PAK are CXCs chemokine kinases targets.
Journal ArticleDOI
CCR5 tyrosine sulfation heterogeneity generates cell surface receptor subpopulations with different ligand binding properties.
Ilaria Scurci,Kalyana Bharati Akondi,Inês De Magalhaes Pinheiro,Marianne Paolini-Bertrand,Alexia Borgeat,Fabrice Cerini,Oliver Hartley +6 more
TL;DR: The first experimental evidence for sulfation heterogeneity of chemokine receptors and its impact on ligand binding is provided, a phenomenon that is important both for the understanding ofchemokine cell biology and for the development of drugs that target chemokin receptors.
Journal ArticleDOI
The upregulation of miR-98-5p affects the glycosylation of IgA1 through cytokines in IgA nephropathy.
TL;DR: In PBMCs, miR-98-5p can target CCL3 to decrease its expression and thereby increase the IL- 6 levels, and the resulting increase in IL-6 can decrease C1GALT1 expression, which indicates that miR -98- 5p might be involved in the development of IgAN.
Book ChapterDOI
Investigating the Role of AMPK in Inflammation
Sarah J. Mancini,Ian P. Salt +1 more
TL;DR: Methods to identify effects of AMPK activity on pro-inflammatory signalling are described, specifically the nuclear localization of the key inflammatory mediators nuclear factor-κB and phosphorylated c-Jun N-terminal kinase and preparation of conditioned medium to analyze the secretion of cytokines/chemokines.
References
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Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Neutrophil recruitment and function in health and inflammation
Elzbieta Kolaczkowska,Paul Kubes +1 more
TL;DR: The key features of the life of a neutrophil are discussed, from its release from bone marrow to its death, and the mechanisms that are used by neutrophils to promote protective or pathological immune responses at different sites are explained.
Journal ArticleDOI
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
TL;DR: Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, two functional subsets among murine blood monocytes are identified: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX (3) CR1(hi)CCS1-dependent recruitment to noninflamed tissues.
Journal ArticleDOI
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Qin Zhang,Mustafa Raoof,Yu Chen,Yuka Sumi,Tolga Sursal,Wolfgang G. Junger,Karim Brohi,Kiyoshi Itagaki,Carl J. Hauser +8 more
TL;DR: It is shown that injury releases mitochondrial DAMPs into the circulation with functionally important immune consequences, including formyl peptides and mitochondrial DNA, which promote PMN Ca2+ flux and phosphorylation of mitogen-activated protein (MAP) kinases, thus leading to PMN migration and degranulation in vitro and in vivo.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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