Journal ArticleDOI
Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
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TLDR
This review focuses on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.Abstract:
Chemokines are chemotactic cytokines that control the migratory patterns and positioning of all immune cells. Although chemokines were initially appreciated as important mediators of acute inflammation, we now know that this complex system of approximately 50 endogenous chemokine ligands and 20 G protein–coupled seven-transmembrane signaling receptors is also critical for the generation of primary and secondary adaptive cellular and humoral immune responses. Recent studies demonstrate important roles for the chemokine system in the priming of naive T cells, in cell fate decisions such as effector and memory cell differentiation, and in regulatory T cell function. In this review, we focus on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.read more
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Journal ArticleDOI
CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis.
Anisyah Ridiandries,Anisyah Ridiandries,Joanne T.M. Tan,Joanne T.M. Tan,Dhanya Ravindran,Dhanya Ravindran,Helen Williams,Heather J. Medbury,Laura A. Lindsay,Clare L. Hawkins,Clare L. Hawkins,Hamish C. G. Prosser,Hamish C. G. Prosser,Christina A. Bursill,Christina A. Bursill +14 more
TL;DR: CC‐chemokine inhibition may be an alternative therapeutic strategy for suppressing diseases associated with inflammatory angiogenesis without inducing the side effects caused by global inhibition.
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Cytokines frequently implicated in myeloproliferative neoplasms.
Yingying Wang,Xuelan Zuo +1 more
TL;DR: CYtokine directed therapy could be an alternative treatment for MPN in future as many cytokines involved in pathogenesis and progression of MPN are critical.
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Identification of Motile Sperm Domain-Containing Protein 2 as Regulator of Human Monocyte Migration.
TL;DR: It is revealed that motile sperm domain–containing protein 2 (MOSPD2), a protein with a previously unknown function, regulates monocyte migration in vitro, and is suggested as a potential target protein for treating diseases in which monocyte and neutrophil accumulation is correlated with pathogenesis.
Journal ArticleDOI
CD8+ T cell immunity blocks the metastasis of carcinogen-exposed breast cancer
Kaiwen Li,Kaiwen Li,Tiancheng Li,Zhaoyi Feng,Mei Huang,Lei Wei,Zhiyu Yan,Mark D. Long,Qiang Hu,Jianmin Wang,Song Liu,Dennis C. Sgroi,Shadmehr Demehri +12 more
TL;DR: The link between carcinogen exposure and cancer immunogenicity is unclear as mentioned in this paper, however, single exposure to 12-dimethylbenz[a]anthracene (DMBA) at puberty accelerated spontaneous breast carcinogenesis in mouse mammary tumor virus-polyoma middle tumor-antigen transgenic (MMTV-PyMTtg or PyMT) and MMTV-Her2/neutg (Her2) mice.
Journal ArticleDOI
GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis.
Alan Le Mercier,Remy Bonnavion,Weijia Yu,Mohamad Wessam Alnouri,Sophie Ramas,Yang Zhang,Yannick Jäger,Kenneth Anthony Roquid,Hyun-Woo Jeong,Kishor K. Sivaraj,Haaglim Cho,Xinyi Chen,Boris Strilic,Tjeerd Sijmonsma,Tjeerd Sijmonsma,Ralf H. Adams,Timm Schroeder,Michael A. Rieger,Stefan Offermanns +18 more
TL;DR: G protein-coupled receptor 182 (GPR182) has been shown to be expressed in endothelial cells; however, its ligand and physiological role has remained elusive as discussed by the authors.
References
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Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Neutrophil recruitment and function in health and inflammation
Elzbieta Kolaczkowska,Paul Kubes +1 more
TL;DR: The key features of the life of a neutrophil are discussed, from its release from bone marrow to its death, and the mechanisms that are used by neutrophils to promote protective or pathological immune responses at different sites are explained.
Journal ArticleDOI
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
TL;DR: Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, two functional subsets among murine blood monocytes are identified: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX (3) CR1(hi)CCS1-dependent recruitment to noninflamed tissues.
Journal ArticleDOI
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Qin Zhang,Mustafa Raoof,Yu Chen,Yuka Sumi,Tolga Sursal,Wolfgang G. Junger,Karim Brohi,Kiyoshi Itagaki,Carl J. Hauser +8 more
TL;DR: It is shown that injury releases mitochondrial DAMPs into the circulation with functionally important immune consequences, including formyl peptides and mitochondrial DNA, which promote PMN Ca2+ flux and phosphorylation of mitogen-activated protein (MAP) kinases, thus leading to PMN migration and degranulation in vitro and in vivo.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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