Journal ArticleDOI
Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
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TLDR
This review focuses on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.Abstract:
Chemokines are chemotactic cytokines that control the migratory patterns and positioning of all immune cells. Although chemokines were initially appreciated as important mediators of acute inflammation, we now know that this complex system of approximately 50 endogenous chemokine ligands and 20 G protein–coupled seven-transmembrane signaling receptors is also critical for the generation of primary and secondary adaptive cellular and humoral immune responses. Recent studies demonstrate important roles for the chemokine system in the priming of naive T cells, in cell fate decisions such as effector and memory cell differentiation, and in regulatory T cell function. In this review, we focus on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.read more
Citations
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Journal ArticleDOI
Potential of Cells and Cytokines/Chemokines to Regulate Tertiary Lymphoid Structures in Human Diseases.
Feifeng Jing,Eun-Young Choi +1 more
TL;DR: The formation of SLO is described, the cellular subsets and molecular cues involved in the formation and maintenance of TLS are described, and the associations of TLS with human diseases, especially autoimmune diseases, are discussed.
Journal ArticleDOI
Immune cell trafficking to the islets during type 1 diabetes.
TL;DR: Current knowledge of the factors that mediate immune cell trafficking to pancreatic islets during T1D progression are described and myeloid cells are described as a convergence point in the pathways controlling this process.
Journal ArticleDOI
TLR ligands, but not modulators of histone modifiers, can induce the complex immune response pattern of endotoxin tolerance in mammary epithelial cells.
TL;DR: Triggering immune functions via the TLR axis, but not through those histone modifiers, induced the beneficial phenomenon of ET in MEC.
Journal ArticleDOI
A Broad Spectrum Chemokine Inhibitor Prevents Preterm Labor but Not Microbial Invasion of the Amniotic Cavity or Neonatal Morbidity in a Non-human Primate Model.
Michelle Coleman,Austyn Orvis,Tsung-Yen Wu,Matthew Dacanay,Sean Merillat,Jason Ogle,Audrey Baldessari,Nicole M Kretzer,Jeff Munson,Adam Boros-Rausch,Oksana Shynlova,Stephen J. Lye,Lakshmi Rajagopal,Lakshmi Rajagopal,Kristina M. Adams Waldorf +14 more
TL;DR: Observations indicate that blocking the chemokine response to infection powerfully suppressed uterine contractility, PTL and the cytokine response, but did not prevent MIAC and fetal pneumonia.
Journal ArticleDOI
Forced Expression of CXCL10 Prevents Liver Metastasis of Colon Carcinoma Cells by the Recruitment of Natural Killer Cells.
TL;DR: Findings indicate that CXCL10 prevents in vivo growth and metastasis of colon carcinoma cells by recruiting NK cells, suggesting that forced expression of CxCL10 in the colon tumors by gene delivery should lead to a favorable clinical outcome.
References
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Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Neutrophil recruitment and function in health and inflammation
Elzbieta Kolaczkowska,Paul Kubes +1 more
TL;DR: The key features of the life of a neutrophil are discussed, from its release from bone marrow to its death, and the mechanisms that are used by neutrophils to promote protective or pathological immune responses at different sites are explained.
Journal ArticleDOI
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
TL;DR: Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, two functional subsets among murine blood monocytes are identified: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX (3) CR1(hi)CCS1-dependent recruitment to noninflamed tissues.
Journal ArticleDOI
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Qin Zhang,Mustafa Raoof,Yu Chen,Yuka Sumi,Tolga Sursal,Wolfgang G. Junger,Karim Brohi,Kiyoshi Itagaki,Carl J. Hauser +8 more
TL;DR: It is shown that injury releases mitochondrial DAMPs into the circulation with functionally important immune consequences, including formyl peptides and mitochondrial DNA, which promote PMN Ca2+ flux and phosphorylation of mitogen-activated protein (MAP) kinases, thus leading to PMN migration and degranulation in vitro and in vivo.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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