Journal ArticleDOI
Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
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TLDR
This review focuses on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.Abstract:
Chemokines are chemotactic cytokines that control the migratory patterns and positioning of all immune cells. Although chemokines were initially appreciated as important mediators of acute inflammation, we now know that this complex system of approximately 50 endogenous chemokine ligands and 20 G protein–coupled seven-transmembrane signaling receptors is also critical for the generation of primary and secondary adaptive cellular and humoral immune responses. Recent studies demonstrate important roles for the chemokine system in the priming of naive T cells, in cell fate decisions such as effector and memory cell differentiation, and in regulatory T cell function. In this review, we focus on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.read more
Citations
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Journal ArticleDOI
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy
TL;DR: This Review focuses on the main chemokines that are found in the human tumour microenvironment, and elaborate on their patterns of expression, their regulation and their roles in immune cell recruitment and in cancer and stromal cell biology.
Journal ArticleDOI
Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.
Yong Xiong,Yuan Liu,Liu Cao,Dehe Wang,Ming Guo,Ao Jiang,Dong Guo,Wenjia Hu,Jiayi Yang,Zhidong Tang,Honglong Wu,Yongquan Lin,Meiyuan Zhang,Qi Zhang,Mang Shi,Yingle Liu,Yu Zhou,Ke Lan,Yu Chen +18 more
TL;DR: The results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/Mip1B.
Journal ArticleDOI
Fever and the thermal regulation of immunity: the immune system feels the heat
TL;DR: The emerging evidence suggesting that the adrenergic signalling pathways associated with thermogenesis shape immune cell function is discussed, as well as the unexpected multiplicity of roles of the pyrogenic cytokine interleukin-6 (IL-6), both during fever induction and during the mobilization of lymphocytes to the lymphoid organs that are the staging ground for immune defence.
Journal ArticleDOI
An Immune Atlas of Clear Cell Renal Cell Carcinoma
Stéphane Chevrier,Jacob H. Levine,Vito R T Zanotelli,Karina Silina,Daniel Schulz,Marina Bacac,Carola Ries,Laurie Ailles,Laurie Ailles,Michael A.S. Jewett,Holger Moch,Maries van den Broek,Christian Beisel,Michael B. Stadler,Michael B. Stadler,Craig Gedye,Bernhard Reis,Dana Pe'er,Bernd Bodenmiller +18 more
TL;DR: In this paper, the authors used mass cytometry with extensive antibody panels to perform in-depth immune profiling of samples from 73 clear cell renal cell carcinoma (ccRCC) patients and five healthy controls.
Journal ArticleDOI
Lineage tracking reveals dynamic relationships of T cells in colorectal cancer.
Lei Zhang,Xin Yu,Liangtao Zheng,Yuanyuan Zhang,Yansen Li,Qiao Fang,Ranran Gao,Boxi Kang,Qiming Zhang,Julie Y. Huang,Hiroyasu Konno,Guo Xinyi,Yingjiang Ye,Songyuan Gao,Shan Wang,Xueda Hu,Xianwen Ren,Zhanlong Shen,Wenjun Ouyang,Zemin Zhang +19 more
TL;DR: An integrated RNA-sequencing approach demonstrates that CXCL13+ TH1-like cells are preferentially enriched in microsatellite-instable tumours from patients with colorectal cancer, and IGFLR1 is identified as a co-stimulatory molecule.
References
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Journal Article
Chemokine receptor CXCR3 facilitates CD8+ T cell differentiation into short-lived effector cells leading to memory degeneration
Journal ArticleDOI
Dynamic imaging of chemokine-dependent CD8+ T cell help for CD8+ T cell responses.
Stéphanie Hugues,Alix Scholer,Alexandre Boissonnas,Alexander Nussbaum,Christophe Combadière,Sebastian Amigorena,Luc Fetler,Luc Fetler +7 more
TL;DR: During the initiation of antigen-specific CD8+ T cell responses, naiveCD8+ polyclonal T cells 'preferentially' interacted in an antigen-independent way with mature dendritic cells competent to present antigen to antigen- specific CD8 + T cells.
Journal ArticleDOI
Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2
J. Pablo Abonia,K. Frank Austen,Barrett J. Rollins,Sunil K. Joshi,Richard A. Flavell,William A. Kuziel,Pandelakis A. Koni,Michael F. Gurish +7 more
TL;DR: The establishment and maintenance of MCps in the small intestine is a dynamic process that requires expression of the alpha4beta7 integrin and the alpha-chemokine receptor CXCR2.
Journal ArticleDOI
CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung
Cyrille Mionnet,Vanessa Buatois,Vanessa Buatois,Akira Kanda,Akira Kanda,Akira Kanda,Valerie Milcent,Valerie Milcent,Sébastien Fleury,Sébastien Fleury,Sébastien Fleury,David Lair,David Lair,Marie Langelot,Marie Langelot,Yannick Lacoeuille,Yannick Lacoeuille,Edith M. Hessel,Robert L. Coffman,Antoine Magnan,Antoine Magnan,David Dombrowicz,David Dombrowicz,David Dombrowicz,Nicolas Glaichenhaus,Nicolas Glaichenhaus,Valérie Julia,Valérie Julia +27 more
TL;DR: It was found that CX3CR1 signaling promoted TH2 survival in the inflamed lungs, and injection of B cell leukemia/lymphoma-2 protein (BCl-2)-transduced CX 3CR1-deficient TH2 cells into CX4+ T cells into mice restored asthma.
Journal ArticleDOI
Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract.
Darren Ruane,Lucas Brane,Bernardo S. Reis,Cheolho Cheong,Cheolho Cheong,Jordan Poles,Yoonkyung Do,Hongfa Zhu,Klara Velinzon,Jae-Hoon Choi,Natalie Studt,Lloyd Mayer,Ed C. Lavelle,Ralph M. Steinman,Daniel Mucida,Saurabh Mehandru +15 more
TL;DR: Lung DCs induce the expression of gut-homing molecules on T cells, resulting in their migration to the GI tract and protection against Salmonella infection after immunization.
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