Journal ArticleDOI
Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
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TLDR
This review focuses on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.Abstract:
Chemokines are chemotactic cytokines that control the migratory patterns and positioning of all immune cells. Although chemokines were initially appreciated as important mediators of acute inflammation, we now know that this complex system of approximately 50 endogenous chemokine ligands and 20 G protein–coupled seven-transmembrane signaling receptors is also critical for the generation of primary and secondary adaptive cellular and humoral immune responses. Recent studies demonstrate important roles for the chemokine system in the priming of naive T cells, in cell fate decisions such as effector and memory cell differentiation, and in regulatory T cell function. In this review, we focus on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.read more
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Journal ArticleDOI
Effects of host‐derived chemokines on the motility and viability of Trypanosoma brucei
Omar A. Alfituri,Olumide Ajibola,James M. Brewer,Paul Garside,Robert A. Benson,Tamlyn Peel,Liam J. Morrison,Neil A. Mabbott +7 more
TL;DR: The data suggest that host‐derived chemokines do not act as chemoattractants for T brucei, and identification of the mechanisms used by trypanosomes to establish host infection will aid the development of novel approaches to block disease transmission.
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Population-specific profiling of CCL3L1 copy number of the three major ethnic groups in Malaysia and the implication on HIV susceptibility.
TL;DR: The CCL3L1 gene CN was found to be strongly associated with ethnicity and associated with reduced HIV susceptibility among the Malays, but the negative results found for the Indian and Chinese need to be further analysed in a larger sample size.
Book ChapterDOI
Mediators of Inflammation
TL;DR: Together, the mediators of inflammation orchestrate all the inflammatory events such as blood vessel dilatation, vascular permeability, leukocyte migration to the affected tissue and pain.
Journal ArticleDOI
Effector Memory–Expressing CD45RA (TEMRA) CD8+ T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor–Dependent Proinflammatory and Migratory Responses
V T Sreedevi,Minyue Zhu +1 more
TL;DR: In this article , the authors showed that TEMRA CD8+T cells from kidney transplant recipients exhibit enhanced migratory properties compared with effector memory CD8 + T cells and that the chemokine CXCL12 not only promotes migration of TEMra CD8−T cells toward nonlymphoid organs but also triggers a purinergic P2X4 receptor-dependent proinflammatory response.
Journal ArticleDOI
CC chemokine receptor 7 promotes macrophage recruitment and induces M2-polarization through CC chemokine ligand 19&21 in oral squamous cell carcinoma
Wanhang Zhou,Yao Wang,Cong Yan,Weimin Du,M. A. Al-Aroomi,Li Wu-Zheng,Shanhong Lin,Jiarang Gao,Sheng Jiang,Zengxu Wang,Chang-Yu Sun,Fa-yu Liu +11 more
TL;DR: In this paper , the authors investigated the impact of CC chemokine receptor 7 (CCR7) on the recruitment and polarization of tumorassociated macrophages (TAMs) in oral squamous cell carcinoma (OSCC).
References
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Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Neutrophil recruitment and function in health and inflammation
Elzbieta Kolaczkowska,Paul Kubes +1 more
TL;DR: The key features of the life of a neutrophil are discussed, from its release from bone marrow to its death, and the mechanisms that are used by neutrophils to promote protective or pathological immune responses at different sites are explained.
Journal ArticleDOI
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
TL;DR: Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, two functional subsets among murine blood monocytes are identified: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX (3) CR1(hi)CCS1-dependent recruitment to noninflamed tissues.
Journal ArticleDOI
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Qin Zhang,Mustafa Raoof,Yu Chen,Yuka Sumi,Tolga Sursal,Wolfgang G. Junger,Karim Brohi,Kiyoshi Itagaki,Carl J. Hauser +8 more
TL;DR: It is shown that injury releases mitochondrial DAMPs into the circulation with functionally important immune consequences, including formyl peptides and mitochondrial DNA, which promote PMN Ca2+ flux and phosphorylation of mitogen-activated protein (MAP) kinases, thus leading to PMN migration and degranulation in vitro and in vivo.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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