Journal ArticleDOI
Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
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TLDR
This review focuses on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.Abstract:
Chemokines are chemotactic cytokines that control the migratory patterns and positioning of all immune cells. Although chemokines were initially appreciated as important mediators of acute inflammation, we now know that this complex system of approximately 50 endogenous chemokine ligands and 20 G protein–coupled seven-transmembrane signaling receptors is also critical for the generation of primary and secondary adaptive cellular and humoral immune responses. Recent studies demonstrate important roles for the chemokine system in the priming of naive T cells, in cell fate decisions such as effector and memory cell differentiation, and in regulatory T cell function. In this review, we focus on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.read more
Citations
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Journal ArticleDOI
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy
TL;DR: This Review focuses on the main chemokines that are found in the human tumour microenvironment, and elaborate on their patterns of expression, their regulation and their roles in immune cell recruitment and in cancer and stromal cell biology.
Journal ArticleDOI
Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.
Yong Xiong,Yuan Liu,Liu Cao,Dehe Wang,Ming Guo,Ao Jiang,Dong Guo,Wenjia Hu,Jiayi Yang,Zhidong Tang,Honglong Wu,Yongquan Lin,Meiyuan Zhang,Qi Zhang,Mang Shi,Yingle Liu,Yu Zhou,Ke Lan,Yu Chen +18 more
TL;DR: The results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/Mip1B.
Journal ArticleDOI
Fever and the thermal regulation of immunity: the immune system feels the heat
TL;DR: The emerging evidence suggesting that the adrenergic signalling pathways associated with thermogenesis shape immune cell function is discussed, as well as the unexpected multiplicity of roles of the pyrogenic cytokine interleukin-6 (IL-6), both during fever induction and during the mobilization of lymphocytes to the lymphoid organs that are the staging ground for immune defence.
Journal ArticleDOI
An Immune Atlas of Clear Cell Renal Cell Carcinoma
Stéphane Chevrier,Jacob H. Levine,Vito R T Zanotelli,Karina Silina,Daniel Schulz,Marina Bacac,Carola Ries,Laurie Ailles,Laurie Ailles,Michael A.S. Jewett,Holger Moch,Maries van den Broek,Christian Beisel,Michael B. Stadler,Michael B. Stadler,Craig Gedye,Bernhard Reis,Dana Pe'er,Bernd Bodenmiller +18 more
TL;DR: In this paper, the authors used mass cytometry with extensive antibody panels to perform in-depth immune profiling of samples from 73 clear cell renal cell carcinoma (ccRCC) patients and five healthy controls.
Journal ArticleDOI
Lineage tracking reveals dynamic relationships of T cells in colorectal cancer.
Lei Zhang,Xin Yu,Liangtao Zheng,Yuanyuan Zhang,Yansen Li,Qiao Fang,Ranran Gao,Boxi Kang,Qiming Zhang,Julie Y. Huang,Hiroyasu Konno,Guo Xinyi,Yingjiang Ye,Songyuan Gao,Shan Wang,Xueda Hu,Xianwen Ren,Zhanlong Shen,Wenjun Ouyang,Zemin Zhang +19 more
TL;DR: An integrated RNA-sequencing approach demonstrates that CXCL13+ TH1-like cells are preferentially enriched in microsatellite-instable tumours from patients with colorectal cancer, and IGFLR1 is identified as a co-stimulatory molecule.
References
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Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo
Tim Lämmermann,Philippe V. Afonso,Bastian R. Angermann,Ji Ming Wang,Wolfgang Kastenmüller,Wolfgang Kastenmüller,Carole A. Parent,Ronald N. Germain +7 more
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Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs
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TL;DR: Current understanding of how Sphingosine-1-phosphate promotes exit from the secondary lymphoid organs and thymus is summarized and how FTY720, a drug that targets S1P receptors and is approved for the treatment of multiple sclerosis, causes immune suppression is examined.
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International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors
Françoise Bachelerie,Adit Ben-Baruch,Amanda M. Burkhardt,Christophe Combadière,Joshua M. Farber,Gerard J. Graham,Richard Horuk,Alexander Hovard Sparre-Ulrich,Massimo Locati,Andrew D. Luster,Alberto Mantovani,Kouji Matsushima,Philip M. Murphy,Robert J. B. Nibbs,Hisayuki Nomiyama,Christine Power,Amanda E. I. Proudfoot,Mette M. Rosenkilde,Antal Rot,Silvano Sozzani,Marcus Thelen,Osamu Yoshie,Albert Zlotnik +22 more
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Journal ArticleDOI
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2
William A. Kuziel,Sharon J. Morgan,Tracey C. Dawson,Stephanie Griffin,Oliver Smithies,Klaus Ley,Nobuyo Maeda +6 more
TL;DR: Results demonstrate that CCR2 is a major regulator of induced macrophage trafficking in vivo and shows enhanced early accumulation and delayed clearance of neutrophils and eosinophils.
Journal ArticleDOI
Memory T Cell Subsets, Migration Patterns, and Tissue Residence
TL;DR: Evidence for tissue-resident memory T cell (TRM) is reviewed, a relatively new player is highlighted, and the potential differences between the migratory patterns of CD4(+) and CD8(+) T cells are emphasized.
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