Journal ArticleDOI
Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
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TLDR
This review focuses on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.Abstract:
Chemokines are chemotactic cytokines that control the migratory patterns and positioning of all immune cells. Although chemokines were initially appreciated as important mediators of acute inflammation, we now know that this complex system of approximately 50 endogenous chemokine ligands and 20 G protein–coupled seven-transmembrane signaling receptors is also critical for the generation of primary and secondary adaptive cellular and humoral immune responses. Recent studies demonstrate important roles for the chemokine system in the priming of naive T cells, in cell fate decisions such as effector and memory cell differentiation, and in regulatory T cell function. In this review, we focus on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.read more
Citations
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Journal ArticleDOI
The sweet spot: how GAGs help chemokines guide migrating cells
Yoan R. Monneau,Yoan R. Monneau,Yoan R. Monneau,Fernando Arenzana-Seisdedos,Hugues Lortat-Jacob,Hugues Lortat-Jacob,Hugues Lortat-Jacob +6 more
TL;DR: A critical analysis of the tools, molecules, and strategies that can be used to structurally and functionally investigate the formation of chemokine–glycosaminoglycan complexes described to date are provided.
Journal ArticleDOI
Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19.
Ronen Alon,Mike Sportiello,Stav Kozlovski,Ashwin B. R. Kumar,Emma C. Reilly,Alexander Zarbock,Natalio Garbi,David J. Topham +7 more
TL;DR: How insights into immune cell trafficking during pneumotropic influenza virus infections may inform understanding of immune cell recruitment to the respiratory tract in patients with coronavirus disease 2019 (COVID-19) are discussed and the emerging knowledge of vascular pathologies beyond the lung caused by severe acute respiratory syndrome coronav virus 2 is examined.
Journal ArticleDOI
Combination strategies to maximize the benefits of cancer immunotherapy.
TL;DR: Wang et al. as mentioned in this paper discussed the relationship between cancer immune response and mechanisms of resistance to immunotherapy, and provided a comprehensive review on the latest clinical status of combination therapies (e.g., immunotherapy with chemotherapy, radiation therapy and targeted therapy).
Journal ArticleDOI
Chemokines and cancer: new immune checkpoints for cancer therapy.
TL;DR: It is shown that CXCL10 acts on CD4+ and CD8+ T cells to enhance anti-tumor immunity, and it is suggested that blocking the CCR8-CCL1 interaction, alone or combined with other immune checkpoint inhibitors, as an approach to treat malignant diseases.
Journal ArticleDOI
Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity.
TL;DR: Pericytes are mural cells that surround endothelial cells in small blood vessels that can respond to a series of pro-inflammatory stimuli and are able to sense different types of danger due to their expression of functional pattern-recognition receptors, contributing to the onset of innate immune responses.
References
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Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Neutrophil recruitment and function in health and inflammation
Elzbieta Kolaczkowska,Paul Kubes +1 more
TL;DR: The key features of the life of a neutrophil are discussed, from its release from bone marrow to its death, and the mechanisms that are used by neutrophils to promote protective or pathological immune responses at different sites are explained.
Journal ArticleDOI
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
TL;DR: Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, two functional subsets among murine blood monocytes are identified: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX (3) CR1(hi)CCS1-dependent recruitment to noninflamed tissues.
Journal ArticleDOI
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Qin Zhang,Mustafa Raoof,Yu Chen,Yuka Sumi,Tolga Sursal,Wolfgang G. Junger,Karim Brohi,Kiyoshi Itagaki,Carl J. Hauser +8 more
TL;DR: It is shown that injury releases mitochondrial DAMPs into the circulation with functionally important immune consequences, including formyl peptides and mitochondrial DNA, which promote PMN Ca2+ flux and phosphorylation of mitogen-activated protein (MAP) kinases, thus leading to PMN migration and degranulation in vitro and in vivo.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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