Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
Susanna B. Park,David Goldstein,Arun V. Krishnan,Cindy S.-Y. Lin,Michael Friedlander,James T. Cassidy,Martin Koltzenburg,Matthew C. Kiernan +7 more
TLDR
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.Abstract:
With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies. CA Cancer J Clin 2013;63:419-437. ©2013 American Cancer Society, Inc.read more
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The usefulness of sLORETA in evaluating the effect of high-dose ARA-C on brain connectivity in patients with acute myeloid leukemia: an exploratory study.
Alessia Zarabla,S Ungania,A Cacciatore,Andrea Maialetti,Gianluca Petreri,Andrea Mengarelli,Antonio Spadea,Francesco Marchesi,Daniela Renzi,Svitlana Gumenyuk,L Strigari,Marta Maschio +11 more
TL;DR: In the patients receiving high-dose Ara-C, a statistically significant reduction in functional connectivity was observed in the fronto-parietal network, which literature data suggest is involved in attentional processes, and highlights the possibility of using novel techniques to study potential CNS toxicity of cancer therapy.
Journal ArticleDOI
Development and consensus process for a clinical pathway for the assessment and management of chemotherapy-induced peripheral neuropathy
David Mizrahi,David Goldstein,Matthew C. Kiernan,Louisa Robinson,O. Pitiyarachchi,Susan Mccullough,Phil Mendoza-Jones,Peter Grimison,Frances M. Boyle,Susanna B. Park +9 more
TL;DR: In this paper , a CIPN clinical pathway (CIPN-path) was developed and reviewed by an expert multi-disciplinary panel and consumers, with consensus defined as ≥ 80% of respondents agreeing with each statement.
Journal ArticleDOI
The Relationship between Oncology Nurses’ Practice behaviors, Knowledge and Confidence regarding Chemotherapy Induced Peripheral Neuropathy
TL;DR: It was concluded that there were no statistically significant relations between oncology nurses' Knowledge with practice behaviors and confidence, there were positive correlation between nurses' knowledge and practice and there were negative correlation between knowledge and confidence but it did not reach a significant level.
Journal ArticleDOI
A Case Series of Snake Venom Pharmacopuncture for Chemotherapy-Induced Peripheral Neuropathy: A Retrospective Observational Study.
TL;DR: The results of this research suggest positive potential benefits of using SVP for treating patients with CIPN and excellent safety results of SVP seen in this research should lead to larger clinical trials aimed at developing SVP into a potential intervention for managing patients with the symptoms of CIPn.
Journal ArticleDOI
Co-expression gene modules involved in cisplatin-induced peripheral neuropathy according to sensitivity, status, and severity.
TL;DR: The results provide possible targets and mechanism insights into the development and progress of CIPN, which can guide further transformation and pre‐clinical research.
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