Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
Susanna B. Park,David Goldstein,Arun V. Krishnan,Cindy S.-Y. Lin,Michael Friedlander,James T. Cassidy,Martin Koltzenburg,Matthew C. Kiernan +7 more
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TLDR
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.Abstract:
With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies. CA Cancer J Clin 2013;63:419-437. ©2013 American Cancer Society, Inc.read more
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Peripheral neuropathy in hematologic malignancies - Past, present and future.
TL;DR: The clinical features and risk factors for peripheral neuropathy following bortezomib, thalidomide, brentuximab vedotin and vinca alkaloid treatment, as well as related compounds are examined.
Journal ArticleDOI
Cisplatin-induced activation and functional modulation of satellite glial cells lead to cytokine-mediated modulation of sensory neuron excitability.
TL;DR: In this article, the influence of cisplatin on the function of satellite glial cells (SGCs) and the direct influence on dorsal root ganglion (DRG) neurons was investigated.
Incidence, Prevalence and Predictors of Chemotherapy Induced Peripheral Neuropathy
Marta Seretny,Gillian L. Currie,Emily S. Sena,Sabrina Ramnarine,Malcolm R. Macleod,Leslie A. Colvin,Marie Fallon +6 more
TL;DR: A systematic review of studies reporting the prevalence of Chemotherapy-induced Q4 peripheral neuropathy found different chemotherapy drugs were associated with differences in CIPN prevalence, and there was some evidence of publication bias.
Journal ArticleDOI
Mobility in survivors with chemotherapy-induced peripheral neuropathy and utility of the 6-min walk test
J. Matt McCrary,David Goldstein,David Wyld,David Wyld,Robert D. Henderson,Robert D. Henderson,Craig R. Lewis,Susanna B. Park,Susanna B. Park +8 more
TL;DR: The 6MWT demonstrates promising utility as a mobility assessment in a CIPN cohort and emphasizes the need for effective interventions to treat and prevent CIPn.
Journal ArticleDOI
Chemotherapy-Induced Peripheral Neuropathy: Use of an Electronic Care Planning System to Improve Adherence to Recommended Assessment and Management Practices.
Robert Knoerl,Celia M. Bridges,Gloria Smith,James J. Yang,Grace A Kanzawa-Lee,Ellen M. Lavoie Smith +5 more
TL;DR: CPS use significantly improved documentation of numbness and nonpainful CIPn management strategies but had no effect on documentation of additional assessment variables or painful CIPN management.
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